Gene Symbol | SPOPL |
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Entrez Gene | 339745 |
Alt Symbol | BTBD33 |
Species | Human |
Gene Type | protein-coding |
Description | speckle-type POZ protein-like |
Other Description | HIB homolog 2|roadkill homolog 2 |
Swissprots | Q6IQ16 |
Accessions | EAX11609 Q6IQ16 AA737682 AK094583 AK293850 BAG57248 BC071613 AAH71613 BX538143 CD643025 CN315400 HQ447434 ADQ31920 XM_005263655 XP_005263712 XM_005263656 XP_005263713 XM_005263657 XP_005263714 XM_011511074 XP_011509376 NM_001001664 NP_001001664 |
Function | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269|PubMed:22632832}. |
Subcellular Location | Nucleus {ECO:0000250}. |
SPOPL (N-16) - sc-139555 from Santa Cruz Biotechnology
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Anti-SPOPL antibody - ab191175 from Abcam
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Anti-SPOPL antibody - ab171126 from Abcam
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Anti-SPOPL antibody - ab81167 from Abcam
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Anti-SPOPL antibody - ab90123 from Abcam
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Anti-SPOPL Antibody (aa74-123) - LS-C82601 from LifeSpan Bioscience
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Anti-SPOPL Antibody (C-Terminus) - LS-C111265 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa221-249) IHC-plus⢠- LS-B10543 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, AP) - LS-C241204 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, Biotin) - LS-C241206 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, APC) - LS-C241207 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, FITC) - LS-C241208 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, PE) - LS-C241209 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357, Azide-free, HRP) - LS-C248241 from LifeSpan Bioscience
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Anti-SPOPL Antibody (aa228-357) - LS-C325346 from LifeSpan Bioscience
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SPOPL Antibody - NBP1-79345 from Novus Biologicals
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SPOPL Antibody - NBP1-79344 from Novus Biologicals
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SPOPL Antibody - NBP1-86315 from Novus Biologicals
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Anti-SPOPL antibody produced in rabbit - HPA034687 from Sigma-Aldrich
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Anti-SPOPL antibody produced in rabbit - SAB2103683 from Sigma-Aldrich
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Anti-SPOPL antibody produced in rabbit - AV50314 from Sigma-Aldrich
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SPOPL antibody - N-terminal region (ARP50314_P050) - ARP50314_P050 from Aviva Systems Biology
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SPOPL antibody - middle region (ARP50315_P050) - ARP50315_P050 from Aviva Systems Biology
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SPOPL-Antibody-Center - AP12768c from Abgent, a WuXi AppTec company
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SPOPL Antibody - middle region (OAAB09049) - OAAB09049 from Aviva Systems Biology
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