| Gene Symbol | SPOPL |
|---|---|
| Entrez Gene | 339745 |
| Alt Symbol | BTBD33 |
| Species | Human |
| Gene Type | protein-coding |
| Description | speckle-type POZ protein-like |
| Other Description | HIB homolog 2|roadkill homolog 2 |
| Swissprots | Q6IQ16 |
| Accessions | EAX11609 Q6IQ16 AA737682 AK094583 AK293850 BAG57248 BC071613 AAH71613 BX538143 CD643025 CN315400 HQ447434 ADQ31920 XM_005263655 XP_005263712 XM_005263656 XP_005263713 XM_005263657 XP_005263714 XM_011511074 XP_011509376 NM_001001664 NP_001001664 |
| Function | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269|PubMed:22632832}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
speckle-type POZ protein-like, ELISA Kit - MBS9331539 from MyBioSource
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Human SPOPL ELISA Kit - E036317 from Biobool
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Human Speckle-type POZ protein-like (SPOPL) ELISA Kit - AE15017HU from ARP American Research Products
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