| Gene Symbol |
SPOPL
|
| Entrez Gene |
339745
|
| Alt Symbol |
BTBD33
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
speckle-type POZ protein-like
|
| Other Description |
HIB homolog 2|roadkill homolog 2
|
| Swissprots |
Q6IQ16
|
| Accessions |
EAX11609 Q6IQ16 AA737682 AK094583 AK293850 BAG57248 BC071613 AAH71613 BX538143 CD643025 CN315400 HQ447434 ADQ31920 XM_005263655 XP_005263712 XM_005263656 XP_005263713 XM_005263657 XP_005263714 XM_011511074 XP_011509376 NM_001001664 NP_001001664
|
| Function |
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269|PubMed:22632832}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|