Gene Symbol | PCGF6 |
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Entrez Gene | 84108 |
Alt Symbol | MBLR, RNF134 |
Species | Human |
Gene Type | protein-coding |
Description | polycomb group ring finger 6 |
Other Description | Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134 |
Swissprots | Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7 |
Accessions | EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530 |
Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
MBLR (Mannose Binding Lectin Receptor), Human, ELISA Kit - E-EL-H1306 from ARP American Research Products
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Polycomb group RING finger protein 6, PCGF6, Human, ELISA Kit - E12055h from ARP American Research Products
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Mannose Binding Lectin Receptor, MBLR, Rabbit, ELISA Kit - E-EL-RB1218 from ARP American Research Products
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Mannose Binding Lectin Receptor, MBLR, Chicken, ELISA Kit - E-EL-Ch1817 from ARP American Research Products
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Mannose Binding Lectin Receptor, MBLR, Porcine, ELISA Kit - E-EL-P0393 from ARP American Research Products
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Mannose Binding Lectin Receptor, MBLR, Guinea Pig, ELISA Kit - E-EL-GP0938 from ARP American Research Products
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Mannose Binding Lectin Receptor, MBLR, Monkey, ELISA Kit - E-EL-MK1487 from ARP American Research Products
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Human MBLR (Mannose Binding Lectin Receptor) ELISA Kit - E-EL-H1306 from Elabscience
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MBLR, ELISA Kit - MBS2507183 from MyBioSource
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Polycomb group RING finger protein 6, ELISA Kit - MBS280855 from MyBioSource
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Mouse PCGF6 ELISA Kit (Custom ELISA) - LS-F16426 from LifeSpan Bioscience
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Rat PCGF6 ELISA Kit (Custom ELISA) - LS-F16427 from LifeSpan Bioscience
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Human MBLR (Mannose Binding Lectin Receptor) ELISA Kit - E-EL-H1306 from Iwai North America Inc.
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Human PCGF6 ELISA Kit (Sandwich ELISA) - LS-F13375 from LifeSpan Bioscience
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PCGF6 - EKH2756 from Nordic BioSite
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PCGF6 ELISA Kit (Human) (OKEH02203) - OKEH02203 from Aviva Systems Biology
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Human MBLR ELISA Kit - E023858 from Biobool
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Human PCGF6 ELISA Kit - E030065 from Biobool
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Human Polycomb group RING finger protein 6 ELISA Kit - EK2953 from Signalway Antibody
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Human Mannma binding lectin receptor (MBLR) ELISA Kit - AE63030HU from ARP American Research Products
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Polycomb group RING finger protein 6, ELISA Kit - MBS9426789 from MyBioSource
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Polycomb group RING finger protein 6, ELISA Kit - MBS2885032 from MyBioSource
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Polycomb group RING finger protein 6, ELISA Kit - MBS761804 from MyBioSource
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Human PCGF6 ELISA Kit (Sandwich ELISA) - LS-F33908 from LifeSpan Bioscience
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