PCGF6

Gene Symbol PCGF6
Entrez Gene 84108
Alt Symbol MBLR, RNF134
Species Human
Gene Type protein-coding
Description polycomb group ring finger 6
Other Description Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134
Swissprots Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7
Accessions EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}.
Tissue Specificity Ubiquitous.
Top Pathways Signaling pathways regulating pluripotency of stem cells

PCGF6 293T Cell Transient Overexpression Lysate(Denatured) - H00084108-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

PCGF6 overexpression lysate - LY410309 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PCGF6 overexpression lysate - LY423286 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PCGF6 Overexpression Lysate (Native) - NBP2-08786 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PCGF6 Overexpression Lysate (Adult Normal) [NBP2-08786] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PCGF6.

PCGF6 Overexpression Lysate (Native) - NBP2-06068 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

PCGF6 Overexpression Lysate (Denatured) - H00084108-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human PCGF6 Knockdown Stable Cell Line - CSC-DC011442 from Creative biogene

Category Cell Line
Species Human
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