| Gene Symbol |
PCGF6
|
| Entrez Gene |
84108
|
| Alt Symbol |
MBLR, RNF134
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polycomb group ring finger 6
|
| Other Description |
Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134
|
| Swissprots |
Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7
|
| Accessions |
EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530
|
| Function |
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|