Gene Symbol | PCGF6 |
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Entrez Gene | 84108 |
Alt Symbol | MBLR, RNF134 |
Species | Human |
Gene Type | protein-coding |
Description | polycomb group ring finger 6 |
Other Description | Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134 |
Swissprots | Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7 |
Accessions | EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530 |
Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
PCGF6 CRISPR/Cas9 KO Plasmid (h) - sc-404420 from Santa Cruz Biotechnology
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PCGF6 HDR Plasmid (h) - sc-404420-HDR from Santa Cruz Biotechnology
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PCGF6 Double Nickase Plasmid (h) - sc-404420-NIC from Santa Cruz Biotechnology
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PCGF6 Double Nickase Plasmid (h2) - sc-404420-NIC-2 from Santa Cruz Biotechnology
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PCGF6 CRISPR Activation Plasmid (h) - sc-404420-ACT from Santa Cruz Biotechnology
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PCGF6 CRISPR Activation Plasmid (h2) - sc-404420-ACT-2 from Santa Cruz Biotechnology
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PCGF6 Lentiviral Activation Particles (h) - sc-404420-LAC from Santa Cruz Biotechnology
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PCGF6 Lentiviral Activation Particles (h2) - sc-404420-LAC-2 from Santa Cruz Biotechnology
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PCGF6 siRNA (h) - sc-90663 from Santa Cruz Biotechnology
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PCGF6 shRNA Plasmid (h) - sc-90663-SH from Santa Cruz Biotechnology
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PCGF6 shRNA (h) Lentiviral Particles - sc-90663-V from Santa Cruz Biotechnology
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PCGF6 RNAi - H00084108-R01 from Novus Biologicals
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PCGF6 RNAi - H00084108-R02 from Novus Biologicals
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MISSION® esiRNA - EHU113591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16475 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16475 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07848 from Sigma-Aldrich
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PCGF6 siRNA (Human) - CRJ3305 from Cohesion Biosciences
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shRNA set against Human PCGF6 (NM_032154.3) - SHH371840 from Creative biogene
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shRNA set against Human PCGF6(NM_001011663.1) - SHR096726 from Creative biogene
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shRNA set against Human PCGF6(NM_032154.3) - SHR096808 from Creative biogene
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Human PCGF6 siRNA - orb273806 from Biorbyt
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PCGF6 shRNA Plasmid (Human) - CHJ3305 from Cohesion Biosciences
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PCGF6 miRNA 3'UTR clone - MiUTR1H-07662 from Creative biogene
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PCGF6 miRNA 3'UTR clone - MiUTR1H-07663 from Creative biogene
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