PCGF6

Gene Symbol PCGF6
Entrez Gene 84108
Alt Symbol MBLR, RNF134
Species Human
Gene Type protein-coding
Description polycomb group ring finger 6
Other Description Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134
Swissprots Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7
Accessions EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}.
Tissue Specificity Ubiquitous.
Top Pathways Signaling pathways regulating pluripotency of stem cells

PCGF6 CRISPR/Cas9 KO Plasmid (h) - sc-404420 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 HDR Plasmid (h) - sc-404420-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 Double Nickase Plasmid (h) - sc-404420-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 Double Nickase Plasmid (h2) - sc-404420-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 CRISPR Activation Plasmid (h) - sc-404420-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 CRISPR Activation Plasmid (h2) - sc-404420-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 Lentiviral Activation Particles (h) - sc-404420-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 Lentiviral Activation Particles (h2) - sc-404420-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF6 siRNA (h) - sc-90663 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCGF6 shRNA Plasmid (h) - sc-90663-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCGF6 shRNA (h) Lentiviral Particles - sc-90663-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCGF6 RNAi - H00084108-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PCGF6 RNAi - H00084108-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113591 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16475 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16475 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07848 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07848

PCGF6 siRNA (Human) - CRJ3305 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PCGF6 (NM_032154.3) - SHH371840 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PCGF6(NM_001011663.1) - SHR096726 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PCGF6(NM_032154.3) - SHR096808 from Creative biogene

Category siRNA
Species Reactivities Human

Human PCGF6 siRNA - orb273806 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PCGF6 shRNA Plasmid (Human) - CHJ3305 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PCGF6 miRNA 3'UTR clone - MiUTR1H-07662 from Creative biogene

Species Reactivities Human

PCGF6 miRNA 3'UTR clone - MiUTR1H-07663 from Creative biogene

Species Reactivities Human
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