Gene Symbol | PCGF6 |
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Entrez Gene | 84108 |
Alt Symbol | MBLR, RNF134 |
Species | Human |
Gene Type | protein-coding |
Description | polycomb group ring finger 6 |
Other Description | Mel18 and Bmi1-like RING finger protein|polycomb group RING finger protein 6|ring finger protein 134 |
Swissprots | Q5SYD6 A8K3R4 Q96SJ1 Q96ID9 Q5SYD1 Q9BYE7 |
Accessions | EAW49647 EAW49648 EAW49649 EAW49650 EAW49651 EAW49652 Q9BYE7 AB047006 BAB40779 AK027885 AK290679 BAF83368 AK309105 BC007602 AAH07602 BC010235 AAH10235 EU446621 ABZ92150 EU447006 ABZ92535 XM_005270213 XP_005270270 XM_011540261 XP_011538563 NM_001011663 NP_001011663 NM_032154 NP_115530 |
Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:21282530}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
PCGF6 (E-15) - sc-160649 from Santa Cruz Biotechnology
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PCGF6 (H-93) - sc-367209 from Santa Cruz Biotechnology
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Anti-RING6a antibody - ab192395 from Abcam
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Anti-RING6a antibody - ab48010 from Abcam
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Anti-RING6a antibody - ab102059 from Abcam
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Anti-RING6a antibody - ab169113 from Abcam
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Anti-PCGF6 Antibody (aa190-217) - LS-C158553 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa261-295) - LS-C344516 from LifeSpan Bioscience
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Anti-PCGF6 Antibody - LS-C155110 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, AP) - LS-C223598 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, APC) - LS-C223599 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, Biotin) - LS-C223600 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, FITC) - LS-C223601 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, PE) - LS-C223603 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa190-217, Azide-free, HRP) - LS-C223602 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa189-217) - LS-C323857 from LifeSpan Bioscience
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Anti-PCGF6 Antibody - LS-C341850 from LifeSpan Bioscience
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Anti-PCGF6 Antibody (aa179-228) - LS-C116232 from LifeSpan Bioscience
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Anti-PCGF6 Antibody - LS-C346095 from LifeSpan Bioscience
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PCGF6 Antibody - NBP1-55372 from Novus Biologicals
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PCGF6 Antibody - H00084108-B01P from Novus Biologicals
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PCGF6 Antibody - NBP1-31986 from Novus Biologicals
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PCGF6 Antibody (2B8) - H00084108-M01 from Novus Biologicals
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Anti-PCGF6 antibody produced in rabbit - SAB2105508 from Sigma-Aldrich
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Monoclonal Anti-PCGF6 antibody produced in mouse - SAB1403393 from Sigma-Aldrich
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