MDM4

Gene Symbol MDM4
Entrez Gene 4194
Alt Symbol HDMX, MDMX, MRP1
Species Human
Gene Type protein-coding
Description MDM4, p53 regulator
Other Description MDM4 protein variant G|MDM4 protein variant Y|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx
Swissprots Q8IV83 O15151 Q32SL2 Q2M2Y2 Q6GS18
Accessions AAO13494 EAW91515 EAW91516 O15151 AB209383 BAD92620 AF007111 AAB62928 AK097188 AK130328 AK223228 BAD96948 AK303626 BAG64634 AK304698 BAG65468 AK310607 AK310903 AY923176 AAY22054 AY949028 AAX51227 BC025993 BC067299 AAH67299 BC105106 AAI05107 BC143431 BC143432 BM475824 BP247507 BP334671 BX108199 BX640923 CAE45961 CA395099 CR749470 CAH18300 KC479043 AGJ70143 KF435149 AGZ93683 KF435150 AGZ93684 XM_006711328 XP_006711391 XM_011509565 XP_011507867 XM_011509566 XP_011507868 XM_011509567 XP_011507869 XM_011509568 XP_011507870 NM_001204171 NP_001191100 NM_001204172 NP_001191101 NM_001278516 NP_001265445 NM_001278517 NP_001265446 NM_001278518 NP_001265447 NM_001278519 NP_001265448 NM_002393 NP_002384
Function Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.
Subcellular Location Nucleus.
Tissue Specificity Expressed in all tissues tested with high levels in thymus.
Top Pathways p53 signaling pathway, MicroRNAs in cancer

MDM4-Over-expression-Lysate - LY12922a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MDM4 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MDM4 gene

MDM4 293T Cell Transient Overexpression Lysate(Denatured) - H00004194-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

MDM4 293 Cell Lysate - 400813 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Mouse

MDMX Overexpression Lysate (Denatured) - H00004194-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

MDMX Overexpression Lysate (Native) - NBL1-12971 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MDMX Overexpression Lysate (Adult Normal) [NBL1-12971] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MDMX.

MDMX (h): 293T Lysate - sc-111488 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

MDM4 Over-expression Lysate Product - GWB-33AD72 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human MDM4 Knockdown Stable Cell Line - CSC-DC009341 from Creative biogene

Category Cell Line
Species Human
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