MDM4

Gene Symbol	MDM4
Entrez Gene	4194
Alt Symbol	HDMX, MDMX, MRP1
Species	Human
Gene Type	protein-coding
Description	MDM4, p53 regulator
Other Description	MDM4 protein variant G|MDM4 protein variant Y|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx
Swissprots	Q8IV83 O15151 Q32SL2 Q2M2Y2 Q6GS18
Accessions	AAO13494 EAW91515 EAW91516 O15151 AB209383 BAD92620 AF007111 AAB62928 AK097188 AK130328 AK223228 BAD96948 AK303626 BAG64634 AK304698 BAG65468 AK310607 AK310903 AY923176 AAY22054 AY949028 AAX51227 BC025993 BC067299 AAH67299 BC105106 AAI05107 BC143431 BC143432 BM475824 BP247507 BP334671 BX108199 BX640923 CAE45961 CA395099 CR749470 CAH18300 KC479043 AGJ70143 KF435149 AGZ93683 KF435150 AGZ93684 XM_006711328 XP_006711391 XM_011509565 XP_011507867 XM_011509566 XP_011507868 XM_011509567 XP_011507869 XM_011509568 XP_011507870 NM_001204171 NP_001191100 NM_001204172 NP_001191101 NM_001278516 NP_001265445 NM_001278517 NP_001265446 NM_001278518 NP_001265447 NM_001278519 NP_001265448 NM_002393 NP_002384
Function	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in all tissues tested with high levels in thymus.
Top Pathways	p53 signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MDMX full length protein - ab114467 from Abcam Category Protein Source Wheat germ Species Human

Human MDMX peptide - ab16383 from Abcam Category Peptide

Human MDMX protein fragment - ab167947 from Abcam Category Protein Source E. coli Species Human

Human MDMX protein fragment - ab114468 from Abcam Category Protein Source Wheat germ Species Human

MDM4 / MDMX Antibody Blocking Peptide - LS-E2764 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM4 / MDMX Antibody Blocking Peptide - LS-E10612 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDM4 / MDMX Antibody Blocking Peptide - LS-E25187 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDMX Partial Recombinant Protein - H00004194-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MDMX Protein - H00004194-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MDM4-Antibody-Center-Blocking-peptide - BP13861c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MDM4 (His Tag) protein - orb171580 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 10 μg, 20 μg Source E. coli Species Human

MDM4 Blocking Peptide - 33R-4100 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MDM4 Blocking Peptide - 33R-6211 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MDM4 - H00004194-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MDM4 - H00004194-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MDM4 - H00004194-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MDM4 - H00004194-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MDM4 fusion protein - Ag12319 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MDM4 - BP001335-C685 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human MDM4 - MDM4-27382TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MDM4 - MDM4-29757TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MDM4, His-tagged - MDM4-194H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MDM4, His-tagged - MDM4-336H from Creative Biomart Category Protein Source E. coli Species Human

Human MDM4 / MDMX Protein (His Tag) - 15395-H07E-10 from Sino Biological Category Protein Prices $108.00, $198.00 Sizes 10 µg, 10 µg Source E. coli Species Human

MDM4(1-137) protein-HIS Epitope - 009-001-S46 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

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