MDM4

Gene Symbol	MDM4
Entrez Gene	4194
Alt Symbol	HDMX, MDMX, MRP1
Species	Human
Gene Type	protein-coding
Description	MDM4, p53 regulator
Other Description	MDM4 protein variant G|MDM4 protein variant Y|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx
Swissprots	Q8IV83 O15151 Q32SL2 Q2M2Y2 Q6GS18
Accessions	AAO13494 EAW91515 EAW91516 O15151 AB209383 BAD92620 AF007111 AAB62928 AK097188 AK130328 AK223228 BAD96948 AK303626 BAG64634 AK304698 BAG65468 AK310607 AK310903 AY923176 AAY22054 AY949028 AAX51227 BC025993 BC067299 AAH67299 BC105106 AAI05107 BC143431 BC143432 BM475824 BP247507 BP334671 BX108199 BX640923 CAE45961 CA395099 CR749470 CAH18300 KC479043 AGJ70143 KF435149 AGZ93683 KF435150 AGZ93684 XM_006711328 XP_006711391 XM_011509565 XP_011507867 XM_011509566 XP_011507868 XM_011509567 XP_011507869 XM_011509568 XP_011507870 NM_001204171 NP_001191100 NM_001204172 NP_001191101 NM_001278516 NP_001265445 NM_001278517 NP_001265446 NM_001278518 NP_001265447 NM_001278519 NP_001265448 NM_002393 NP_002384
Function	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in all tissues tested with high levels in thymus.
Top Pathways	p53 signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat MDM4 / MDMX ELISA Kit (Cell-Based ELISA) - LS-F2137 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-Phospho HdmX/MDM4 (S403) Antibody, Affinity Purified - PLA0102 from Sigma-Aldrich Prices $386.00 Sizes 100 µl

Goat anti-HdmX/MDM4 Antibody, Affinity Purified - PLA0297 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human MRP1 ELISA Kit - abx152381 from Abbexa Category ELISA Kit Sensitivity 12.4 pg/ml Range 31.25 pg/ml - 2000 pg/ml

E3 ubiquitin-protein ligase Mdm2 (MDM2), Human, ELISA Kit - CSB-EL013626HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Mdm2 p53 Binding Protein Homolog (MDM2), Human, ELISA Kit - SEG790Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.064ng/mL Range 0.156-10ng/mL

Multidrug Resistance Associated Protein 1, MRP1, Human, ELISA Kit - E-EL-H2012 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Multidrug Resistance Associated Protein 1, MRP1, Rabbit, ELISA Kit - E-EL-RB0265 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Multidrug Resistance Associated Protein 1, MRP1, Chicken, ELISA Kit - E-EL-Ch0579 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Multidrug Resistance Associated Protein 1, MRP1, Porcine, ELISA Kit - E-EL-P1077 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Multidrug Resistance Associated Protein 1, MRP1, Sheep, ELISA Kit - E-EL-S0979 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Multidrug Resistance Associated Protein 1, MRP1, Guinea Pig, ELISA Kit - E-EL-GP0484 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Multidrug Resistance Associated Protein 1, MRP1, Monkey, ELISA Kit - E-EL-MK1442 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

MDM4 (Human) IP-WB Antibody Pair - H00004194-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MDM4 (Human) Matched Antibody Pair - H00004194-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MDM4 (Human) Matched Antibody Pair - H00004194-AP22 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MDM4 Colorimetric Cell-Based ELISA Kit - CB5437 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human MRP1(Multidrug Resistance Associated Protein 1) ELISA Kit - E-EL-H2012 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human MRP1 (Multidrug Resistance Associated Protein 1) CLIA Kit - E-CL-H1220 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Mdm4 p53 binding protein homolog (mouse) , ELISA Kit - MBS9333300 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MRP1, ELISA Kit - MBS2503482 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

ELISA Kit for Mdm2 p53 Binding Protein Homolog (MDM2) - SEG790Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PIR(Pirin) ELISA Kit - E-EL-H2012 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mLng/mL Range 0.31~20 ng/mL

Human MRP1 (Multidrug Resistance Associated Protein 1) CLIA Kit - E-CL-H1220 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Human MRP1 ELISA Kit - abx575623 from Abbexa Category ELISA Kit Sensitivity 12.4 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Search more