MDM4

Gene Symbol	MDM4
Entrez Gene	4194
Alt Symbol	HDMX, MDMX, MRP1
Species	Human
Gene Type	protein-coding
Description	MDM4, p53 regulator
Other Description	MDM4 protein variant G|MDM4 protein variant Y|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx
Swissprots	Q8IV83 O15151 Q32SL2 Q2M2Y2 Q6GS18
Accessions	AAO13494 EAW91515 EAW91516 O15151 AB209383 BAD92620 AF007111 AAB62928 AK097188 AK130328 AK223228 BAD96948 AK303626 BAG64634 AK304698 BAG65468 AK310607 AK310903 AY923176 AAY22054 AY949028 AAX51227 BC025993 BC067299 AAH67299 BC105106 AAI05107 BC143431 BC143432 BM475824 BP247507 BP334671 BX108199 BX640923 CAE45961 CA395099 CR749470 CAH18300 KC479043 AGJ70143 KF435149 AGZ93683 KF435150 AGZ93684 XM_006711328 XP_006711391 XM_011509565 XP_011507867 XM_011509566 XP_011507868 XM_011509567 XP_011507869 XM_011509568 XP_011507870 NM_001204171 NP_001191100 NM_001204172 NP_001191101 NM_001278516 NP_001265445 NM_001278517 NP_001265446 NM_001278518 NP_001265447 NM_001278519 NP_001265448 NM_002393 NP_002384
Function	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in all tissues tested with high levels in thymus.
Top Pathways	p53 signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MDM4 Gene cDNA Clone - orb144219 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-MDM4-cDNA-Clone - DC08601 from Abgent, a WuXi AppTec company Prices $661.50 Sizes 10 µg Species Human Accession BC067299

MDM4 - MBS1275346 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC067299

Human MDM4 ORF Clone(NM_002393.4) - CDCL169842 from Creative Biomart Species Human Accession NM_002393.4

Human MDM4 ORF Clone(NM_001204171.1) - CDCL169843 from Creative Biomart Species Human Accession NM_001204171.1

Human MDM4 / MDMX Gene ORF cDNA clone in cloning vector - HG15395-G from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-HA tag - HG15395-NY from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15395-ACG from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15395-CF from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-His tag - HG15395-NH from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15395-NM from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15395-CM from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-His tag - HG15395-CH from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid - HG15395-UT from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-HA tag - HG15395-CY from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15395-ANG from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15395-ACR from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15395-ANR from Sino Biological Species Human

Human MDM4 / MDMX Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15395-NF from Sino Biological Species Human

Human MDM4 ORF clone (NM_001204172.1) - CDCL131547 from Creative biogene Species Human

Human MDM4 ORF Clone (BC067299) - CDCS409606 from Creative biogene Species Human Accession O15151

Human MDM4 ORF clone (BC067299) - CDCB158202 from Creative biogene Species Human

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