MDM4

Gene Symbol MDM4
Entrez Gene 4194
Alt Symbol HDMX, MDMX, MRP1
Species Human
Gene Type protein-coding
Description MDM4, p53 regulator
Other Description MDM4 protein variant G|MDM4 protein variant Y|MDM4-related protein 1|Mdm4 p53 binding protein homolog|double minute 4, human homolog of; p53-binding protein|mdm2-like p53-binding protein|protein Mdm4|protein Mdmx
Swissprots Q8IV83 O15151 Q32SL2 Q2M2Y2 Q6GS18
Accessions AAO13494 EAW91515 EAW91516 O15151 AB209383 BAD92620 AF007111 AAB62928 AK097188 AK130328 AK223228 BAD96948 AK303626 BAG64634 AK304698 BAG65468 AK310607 AK310903 AY923176 AAY22054 AY949028 AAX51227 BC025993 BC067299 AAH67299 BC105106 AAI05107 BC143431 BC143432 BM475824 BP247507 BP334671 BX108199 BX640923 CAE45961 CA395099 CR749470 CAH18300 KC479043 AGJ70143 KF435149 AGZ93683 KF435150 AGZ93684 XM_006711328 XP_006711391 XM_011509565 XP_011507867 XM_011509566 XP_011507868 XM_011509567 XP_011507869 XM_011509568 XP_011507870 NM_001204171 NP_001191100 NM_001204172 NP_001191101 NM_001278516 NP_001265445 NM_001278517 NP_001265446 NM_001278518 NP_001265447 NM_001278519 NP_001265448 NM_002393 NP_002384
Function Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.
Subcellular Location Nucleus.
Tissue Specificity Expressed in all tissues tested with high levels in thymus.
Top Pathways p53 signaling pathway, MicroRNAs in cancer

MDMX CRISPR/Cas9 KO Plasmid (h) - sc-417855 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX HDR Plasmid (h) - sc-417855-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX Double Nickase Plasmid (h) - sc-417855-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX Double Nickase Plasmid (h2) - sc-417855-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX CRISPR Activation Plasmid (h) - sc-417855-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX CRISPR Activation Plasmid (h2) - sc-417855-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX Lentiviral Activation Particles (h) - sc-417855-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX Lentiviral Activation Particles (h2) - sc-417855-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MDMX siRNA (h) - sc-37448 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MDMX shRNA Plasmid (h) - sc-37448-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MDMX shRNA (h) Lentiviral Particles - sc-37448-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MDMX RNAi - H00004194-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU005381 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13145 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13145 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MDM4 siRNA (Human) - CRH2854 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MDM4 (NM_002393.4) - SHH339687 from Creative biogene

Category siRNA
Species Reactivities Human

Human MDM4 siRNA - orb263356 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MDM4 shRNA Plasmid (Human) - CHH2854 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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