IL1R1

Gene Symbol IL1R1
Entrez Gene 3554
Alt Symbol CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80
Species Human
Gene Type protein-coding
Description interleukin 1 receptor, type I
Other Description CD121 antigen-like family member A|IL-1R-1|IL-1RT-1|IL-1RT1|interleukin 1 receptor alpha, type I|interleukin-1 receptor alpha|interleukin-1 receptor type 1|interleukin-1 receptor type I
Swissprots Q587I7 P14778
Accessions AAM88423 AAX81988 CAD57171 CCF76934 EAX01799 P14778 AK026803 AK314433 AL548240 BC067506 AAH67506 BC067507 AAH67507 BC067508 AAH67508 BC075062 AAH75062 BC075063 AAH75063 BE144272 BQ021163 DA861783 HY092388 M27492 AAA59137 X16896 CAA34773 XM_005263929 XP_005263986 XM_005263930 XP_005263987 XM_005263931 XP_005263988 XM_005263932 XP_005263989 XM_005263933 XP_005263990 XM_005263934 XP_005263991 XM_011511114 XP_011509416 XM_011511115 XP_011509417 XM_011511116 XP_011509418 XM_011511117 XP_011509419 XM_011511118 XP_011509420 XM_011511119 XP_011509421 XM_011511120 XP_011509422 NM_000877 NP_000868 NM_001288706 NP_001275635
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.
Subcellular Location Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
Top Pathways Amoebiasis, Inflammatory mediator regulation of TRP channels, HTLV-I infection, Osteoclast differentiation, Cytokine-cytokine receptor interaction

IL-1RI (102) - sc-66054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

IL-1RI (H-8) - sc-393998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1RI (H-8): sc-393998. Western blot analysis of IL-1RI expression in RAW 264.7 (A), CCRF-CEM (B) and HeLa (C) whole cell lysates.

IL-1RI (C-20) - sc-687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-1RI (C-20): sc-687. Western blot analysis of IL-1RI expression in Hep G2 whole cell lysate.

IL-1RI (H-150) - sc-25775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

IL-1RI (N-20) - sc-688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-1RI (N-20): sc-688. Western blot analysis of IL-1RI expression in CCRF-CEM whole cell lysate.

p-IL-1RI (Tyr 496) - sc-130195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-IL-1RI (Tyr 496): sc-130195. Western blot analysis of p-IL-1RI expression in mouse liver tissue extract.

Anti-IL1 Receptor I antibody - ab106278 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL1 Receptor I antibody (ab106278) at 1/500 dilutionLane 1 : Human fetal spleen lysateLane 2 : HeLa cell lysate

Anti-IL1 Receptor I antibody - ab94393 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL1 Receptor I antibody (ab94393) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 3 : Lung (Human) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL1 Receptor I antibody - ab2575 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-IL1 Receptor I antibody - ab19173 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-IL1 Receptor I antibody - ab87550 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1 Receptor I antibody [35730.111] - ab50563 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 35730.111

Anti-IL1 Receptor I antibody [40101] - ab115497 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 40101
ab115497, at 10 &microg/ml, staining IL1 Receptor I in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IL1 Receptor I antibody [BDI204] - ab20876 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BDI204

Anti-IL1 Receptor I antibody (Biotin) - ab87551 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1 Receptor I antibody - C-terminal - ab190078 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, macrophages labeling IL1 Receptor I with ab190078 at 5 µg/ml.

Anti-IL1 Receptor I antibody - C-terminal - ab154524 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast carcinoma tissue, labeling IL1 Receptor I using ab154524 at a 1/500 dilution.

Anti-IL1R1 Antibody (clone Reg21) - LS-C202396 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone Reg21

Anti-IL1R1 Antibody (clone D14e3) - LS-C202399 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone D14e3

Anti-IL1R1 Antibody (clone D1f3) - LS-C202398 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone D1f3

Anti-IL1R1 Antibody (clone Reg20) - LS-C202397 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone Reg20

Anti-IL1R1 Antibody (aa421-450, AP) - LS-C260130 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL1R1 Antibody (aa421-450, APC) - LS-C260131 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL1R1 Antibody (aa421-450, Biotin) - LS-C260132 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL1R1 Antibody (aa421-450, FITC) - LS-C260133 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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