IL1R1

Gene Symbol	IL1R1
Entrez Gene	3554
Alt Symbol	CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor, type I
Other Description	CD121 antigen-like family member A|IL-1R-1|IL-1RT-1|IL-1RT1|interleukin 1 receptor alpha, type I|interleukin-1 receptor alpha|interleukin-1 receptor type 1|interleukin-1 receptor type I
Swissprots	Q587I7 P14778
Accessions	AAM88423 AAX81988 CAD57171 CCF76934 EAX01799 P14778 AK026803 AK314433 AL548240 BC067506 AAH67506 BC067507 AAH67507 BC067508 AAH67508 BC075062 AAH75062 BC075063 AAH75063 BE144272 BQ021163 DA861783 HY092388 M27492 AAA59137 X16896 CAA34773 XM_005263929 XP_005263986 XM_005263930 XP_005263987 XM_005263931 XP_005263988 XM_005263932 XP_005263989 XM_005263933 XP_005263990 XM_005263934 XP_005263991 XM_011511114 XP_011509416 XM_011511115 XP_011509417 XM_011511116 XP_011509418 XM_011511117 XP_011509419 XM_011511118 XP_011509420 XM_011511119 XP_011509421 XM_011511120 XP_011509422 NM_000877 NP_000868 NM_001288706 NP_001275635
Function	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.
Subcellular Location	Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
Top Pathways	Amoebiasis, Inflammatory mediator regulation of TRP channels, HTLV-I infection, Osteoclast differentiation, Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL1R1 293T Cell Transient Overexpression Lysate(Denatured) - H00003554-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IL1R1 overexpression lysate - LY424475 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL-1 RI Overexpression Lysate (Denatured) - H00003554-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Cynomolgus IL1R1 HEK293 Cell Lysate (WB positive control) - 90279-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus IL1R1 HEK293 Cell Lysate (WB positive control) - 90279-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human IL1R1 / CD121a HEK293 Cell Lysate (WB positive control) - 10126-HCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R1 / CD121a HEK293 Cell Lysate (WB positive control) - 10126-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R1 / CD121a HEK293 Cell Lysate (WB positive control) - 10126-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL-1RA / IL1RN HEK293 Cell Lysate (WB positive control) - 10123-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R1 Human Cells Transfected Lysate (positive control) (denatured) - orb174549 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human IL1R1 Human Cells Transfected Lysate (positive control) (denatured) - orb173119 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

IL-1 RI Overexpression Lysate (Denatured) - H00003554-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human IL1R1 Human Cells Transfected Lysate (positive control) (denatured) - orb173118 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human IL1R1 Knockdown Stable Cell Line - CSC-DC007562 from Creative biogene Category Cell Line Species Human

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