IL1R1

Gene Symbol	IL1R1
Entrez Gene	3554
Alt Symbol	CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor, type I
Other Description	CD121 antigen-like family member A|IL-1R-1|IL-1RT-1|IL-1RT1|interleukin 1 receptor alpha, type I|interleukin-1 receptor alpha|interleukin-1 receptor type 1|interleukin-1 receptor type I
Swissprots	Q587I7 P14778
Accessions	AAM88423 AAX81988 CAD57171 CCF76934 EAX01799 P14778 AK026803 AK314433 AL548240 BC067506 AAH67506 BC067507 AAH67507 BC067508 AAH67508 BC075062 AAH75062 BC075063 AAH75063 BE144272 BQ021163 DA861783 HY092388 M27492 AAA59137 X16896 CAA34773 XM_005263929 XP_005263986 XM_005263930 XP_005263987 XM_005263931 XP_005263988 XM_005263932 XP_005263989 XM_005263933 XP_005263990 XM_005263934 XP_005263991 XM_011511114 XP_011509416 XM_011511115 XP_011509417 XM_011511116 XP_011509418 XM_011511117 XP_011509419 XM_011511118 XP_011509420 XM_011511119 XP_011509421 XM_011511120 XP_011509422 NM_000877 NP_000868 NM_001288706 NP_001275635
Function	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.
Subcellular Location	Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
Top Pathways	Amoebiasis, Inflammatory mediator regulation of TRP channels, HTLV-I infection, Osteoclast differentiation, Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cow IL1 Receptor I full length protein - ab128520 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Bovine

Human IL1 Receptor I protein fragment - ab158755 from Abcam Category Protein Source Wheat germ Species Human

IL1 Receptor I protein (Fc Chimera) - ab83575 from Abcam Category Protein Source HEK 293 cells Species Human

IL1 Receptor I peptide - ab107456 from Abcam Category Peptide

IL1R1 Antibody Blocking Peptide - LS-E2870 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL1R1 Blocking Peptide - LS-E7280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL1R1 Antibody Blocking Peptide - LS-E23307 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL-1 RI Partial Recombinant Protein - H00003554-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL-1 RI Recombinant Protein - P3674 from Novus Biologicals Category Protein Prices $689.00 Sizes 20 µg Species Human

IL-1 RI Recombinant Protein - H00003554-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

IL-1 RI Peptide - P1337 from Novus Biologicals Category Peptide Species Human

IL-1 RI Recombinant Protein - P3829 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IL1R1-Antibody-C-term-Blocking-peptide - BP13994b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-IL1RY496-Antibody-Blocking-peptide - BP3131a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Recombinant Human IL-1 RI - 269-1R-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp21-Thr332

Recombinant Human IL-1 RI, CF - 269-1R-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp21-Thr332

Human IL1R1 protein - orb139157 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human IL1 Receptor Antagonist protein - orb80054 from Biorbyt Category Protein Prices $221.00, $357.00, $434.00 Sizes 20 μg, 100 μg, 250 μg Source E.coli

Cynomolgus IL1R1 protein - orb139158 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Cynomolgus IL1R1 protein (His Tag) - orb139159 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

IL1RA peptide - orb72859 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Human IL1R1 Protein - abx067414 from Abbexa Category Protein Source E.coli Species Human

Human IL1R1 Protein - abx067416 from Abbexa Category Protein Source E.coli Species Human

Human IL1R1 Protein - abx067417 from Abbexa Category Protein Source E.coli Species Human

CD121a / IL1R1 - H00003554-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

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