KEAP1

Gene Symbol KEAP1
Entrez Gene 9817
Alt Symbol INrf2, KLHL19
Species Human
Gene Type protein-coding
Description kelch-like ECH-associated protein 1
Other Description cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways Ubiquitin mediated proteolysis

KEAP1 (D1G10) Rabbit mAb - 7705 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1G10
Western blot analysis of extracts from various cell lines using KEAP1 (D1G10) Rabbit mAb.

KEAP1 (P586) Antibody - 4678 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from OVCAR-8, Jurkat and HEL cells using KEAP1 (P586) Antibody.

KEAP1 (D6B12) Rabbit mAb - 8047 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6B12
Western blot analysis of extracts from various cell lines using KEAP1 (D6B12) Rabbit mAb.

KEAP1 (H436) Antibody - 4617 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using KEAP1 (H436) Antibody.

Keap1 (G-2) - sc-365626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Keap1 (G-2): sc-365626. Western blot analysis of Keap1 expression in Hep G2 whole cell lysate.

Keap1 (H-190) - sc-33569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Keap1 (H-190): sc-33569. Western blot analysis of Keap1 expression in non-transfected: sc-117752 (A) and human Keap1 transfected: sc-171655 (B) 293T whole cell lysates.

Keap1 (C-17) - sc-33894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Keap1 (C-17): sc-33894. Western blot analysis of Keap1 expression in non-transfected: sc-117752 (A) and human Keap1 transfected: sc-171655 (B) 293T whole cell lysates.

Keap1 (E-20) - sc-15246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Keap1 (E-20): sc-15246. Western blot analysis of Keap1 expression in A-673 whole cell lysate.

Keap1 (N-19) - sc-15244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Keap1 (N-19): sc-15244. Western blot analysis of Keap1 expression in non-transfected: sc-117752 (A) and human Keap1 transfected: sc-171655 (B) 293T whole cell lysates.

Anti-Keap1 antibody - ab139729 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Keap1 in Human lung tissue with ab139727 at 20 ug/mL.

Anti-Keap1 antibody - ab196346 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Keap1 antibody [1B4] - ab119403 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B4
All lanes : Anti-Keap1 antibody [1B4] (ab119403) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Keap1 cDNALysates/proteins at 5 µg per lane.developed using the ECL technique

Anti-Keap1 antibody [EPR1805(2)] - ab181144 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1805(2)
All lanes : Anti-Keap1 antibody [EPR1805(2)] (ab181144) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Raji cell lysateLane 3 : NIH:OVCAR-3 cell lysateLane 4 : 293 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-Keap1 antibody - C-terminal - ab189952 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate tissue labeling Keap1 with ab189952 at 2.5 µg/ml.

Anti-KEAP1 Antibody (clone 1B4) - LS-C172468 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B4
IHC of paraffin-embedded Human endometrium tissue using anti-KEAP1 mouse monoclonal antibody.

Anti-KEAP1 Antibody (aa46-60) - LS-C312813 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of KEAP1 antibody. All lanes: Anti-KEAP1 at 0.5ug/ml. Lane 1: U87 Whole Cell Lysate at 40ug. Lane 2: HT1080 Whole Cell Lysate at 40ug. Lane 3: PANC Whole Cell Lysate at 40ug. Predicted bind size: 70KD. Observed bind size: 70KD.

Anti-KEAP1 Antibody (aa21-70) IHC-plus™ - LS-B5612 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KEAP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5612 concentration 5 ug/ml.

Anti-KEAP1 Antibody - LS-C332085 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HEK-293 cell lines, using KEAP1 antibody.

Anti-KEAP1 Antibody (clone 1G2) - LS-C172442 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G2
Anti-KEAP1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KEAP1.

Anti-KEAP1 Antibody - LS-C331712 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat spleen using KEAP1 antibody at dilution of 1:200 (x400 lens)

Anti-KEAP1 Antibody (aa41-53) IHC-plus™ - LS-B8363 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-KEAP1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8363 dilution 3.75 ug/ml.

Anti-KEAP1 Antibody (C-Terminus) IHC-plus™ - LS-B8871 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KEAP1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KEAP1 Antibody (C-Terminus) - LS-C30395 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KEAP1 antibody LS-C30395 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-KEAP1 Antibody (aa543-592) - LS-C31774 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
KEAP1 antibody LS-C31774 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-KEAP1 Antibody (aa422-449) - LS-C165469 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
KEAP1 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The KEAP1 antibody detected the KEAP1 protein (arrow).
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