KEAP1

Gene Symbol KEAP1
Entrez Gene 9817
Alt Symbol INrf2, KLHL19
Species Human
Gene Type protein-coding
Description kelch-like ECH-associated protein 1
Other Description cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways Ubiquitin mediated proteolysis

Kelch-like ECH-associated protein 1 (KEAP1), Human, ELISA Kit - CSB-EL012147HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Kelch-like ECH-associated protein 1 (KEAP1), Human, ELISA Kit - E01K0086 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Kelch Like ECH Associated Protein 1 (KEAP1), ELISA Kit - MBS2024975 from MyBioSource

Category ELISA Kit
Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.053ng/mL.
Range 0.156-10ng/mL

Kelch like ECH associated protein 1 (KEAP1), ELISA Kit - MBS7202133 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch Like ECH Associated Protein 1 (KEAP1), ELISA Kit - MBS2025107 from MyBioSource

Category ELISA Kit
Prices $420.00, $625.00, $855.00, $3,510.00, $6,365.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.055ng/mL.
Range 0.156-10ng/mL

kelch-like ECH-associated protein 1, ELISA Kit - MBS936418 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 6.25 pg /ml.
Range 25 pg/ml -1600 pg/ml.

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7216409 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7215143 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7226944 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7209044 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7222874 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7217502 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7218529 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7202152 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7212746 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Kelch-like ECH-associated protein 1 (KEAP1), ELISA Kit - MBS7239661 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) - SEL648Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) - SEL648Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit - CSB-EL012147HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) - SEL648Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human KEAP1 ELISA Kit (Sandwich ELISA) - LS-F25590 from LifeSpan Bioscience

Category ELISA Kit
Prices $850.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

Mouse KEAP1 ELISA Kit (Sandwich ELISA) - LS-F25591 from LifeSpan Bioscience

Category ELISA Kit
Prices $880.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

Human KEAP1(Kelch-like ECH-associated protein 1) ELISA Kit - E-EL-H2515 from Elabscience

Category ELISA Kit
Sensitivity 0.19 ng/mL
Range 0.31—20 ng/mL

Human KEAP1 ELISA Kit - E021383 from Biobool

Category ELISA Kit
Sensitivity Typically less than 0.053ng/mL.

KEAP1 ELISA Kit (Human) (OKCD00608) - OKCD00608 from Aviva Systems Biology

Category ELISA Kit
Prices $585.00
Sizes 96 wells
Sensitivity < 0.056 ng/mL
Range 0.156-10 ng/mL
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