KEAP1

Gene Symbol	KEAP1
Entrez Gene	9817
Alt Symbol	INrf2, KLHL19
Species	Human
Gene Type	protein-coding
Description	kelch-like ECH-associated protein 1
Other Description	cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots	Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions	AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KEAP1-Over-expression-Lysate - LY11421a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

KEAP1 293 Cell Lysate - 401923 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

KEAP1 293 Cell Lysate - 403305 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Keap1 Overexpression Lysate (Native) - NBL1-12226 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Keap1 Overexpression Lysate (Native) - NBL1-12225 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Keap1 (h2): 293T Lysate - sc-171655 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

KEAP1 Over-expression Lysate Product - GWB-44E3C1 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

KEAP1 Over-expression Lysate Product - GWB-24E854 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human KEAP1 / INRF2 Insect Cell Lysate (WB positive control) - 11981-HNCBL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human KEAP1 / INRF2 Insect Cell Lysate (WB positive control) - 11981-H29BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human KEAP1 / INRF2 Insect Cell Lysate (WB positive control) - 11981-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human KEAP1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175042 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human KEAP1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175268 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

KEAP1-knockout Cell lysate - LC810295 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human KEAP1 Knockdown Stable Cell Line - CSC-DC008059 from Creative biogene Category Cell Line Species Human

Human KEAP1 Knockout Cell Line-HeLa - CSC-RT0564 from Creative biogene Category Cell Line Species Human

KEAP1 KO Cell Lysate-HeLa - CLKO-0069 from Creative biogene Category Cell Lysate

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