KEAP1

Gene Symbol	KEAP1
Entrez Gene	9817
Alt Symbol	INrf2, KLHL19
Species	Human
Gene Type	protein-coding
Description	kelch-like ECH-associated protein 1
Other Description	cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots	Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions	AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® KEAP1 siRNA II - 5289 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® KEAP1 siRNA I - 5285 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Keap1 CRISPR/Cas9 KO Plasmid (h) - sc-400190 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 HDR Plasmid (h) - sc-400190-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 Double Nickase Plasmid (h) - sc-400190-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 Double Nickase Plasmid (h2) - sc-400190-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 CRISPR Activation Plasmid (h) - sc-400190-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 CRISPR Activation Plasmid (h2) - sc-400190-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 Lentiviral Activation Particles (h) - sc-400190-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 Lentiviral Activation Particles (h2) - sc-400190-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Keap1 siRNA (h) - sc-43878 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Keap1 shRNA Plasmid (h) - sc-43878-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Keap1 shRNA (h) Lentiviral Particles - sc-43878-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU065431 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11041 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11041 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04729 from Sigma-Aldrich Category miRNA

KEAP1 siRNA (Human) - CRH6573 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human KEAP1 (NM_012289.3) - SHH324315 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KEAP1(NM_012289.3) - SHL193998 from Creative biogene Category siRNA Species Reactivities Human

Keap1 siRNA (h2) - sc-156042 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Keap1 shRNA Plasmid (h2) - sc-156042-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Keap1 shRNA (h2) Lentiviral Particles - sc-156042-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KEAP1 shRNA Plasmid (Human) - CHH6573 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KEAP1 miRNA 3'UTR clone - MiUTR1H-05189 from Creative biogene Species Reactivities Human

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