KEAP1

Gene Symbol	KEAP1
Entrez Gene	9817
Alt Symbol	INrf2, KLHL19
Species	Human
Gene Type	protein-coding
Description	kelch-like ECH-associated protein 1
Other Description	cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots	Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions	AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytosolic inhibitor of Nrf2 Gene - orb92132 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-KEAP1-cDNA-Clone - DC00942 from Abgent, a WuXi AppTec company Prices $842.40 Sizes 10 µg Species Human Accession BC002417

KEAP1 - MBS1275427 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC002417

Human KEAP1 cDNA clone(NM_203500.1) - CDFG013579 from Creative Biomart Species Human Accession NM_203500.1

Human KEAP1 cDNA clone(NM_012289.3) - CDFH009752 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF clone(NM_012289.3) - CDCL185029 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF Clone(NM_012289.3) - CDCR295774 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF Clone(NM_012289.3) - CDCR295775 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF Clone(NM_012289.3) - CDCR295776 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF Clone(NM_203500.1) - CDCR327479 from Creative Biomart Species Human Accession NM_203500.1

Human KEAP1 ORF Clone(NM_203500.1) - CDCR327480 from Creative Biomart Species Human Accession NM_203500.1

Human KEAP1 ORF Clone(NM_203500.1) - CDCR327481 from Creative Biomart Species Human Accession NM_203500.1

Human KEAP1 ORF Clone(NM_012289.3) - CDCL167843 from Creative Biomart Species Human Accession NM_012289.3

Human KEAP1 ORF Clone(NM_012289.3) - CDCL167844 from Creative Biomart Species Human Accession NM_012289.3

Rat KEAP1 ORF clone(NM_057152.1) - CDCR005138 from Creative Biomart

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone in cloning vector - HG11981-M from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11981-CY from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11981-ACG from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11981-NF from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11981-NY from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11981-ANG from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11981-CF from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11981-NM from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11981-NH from Sino Biological Species Human

Human KEAP1/KEAP-1/INRF2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11981-CM from Sino Biological Species Human

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