KEAP1

Gene Symbol	KEAP1
Entrez Gene	9817
Alt Symbol	INrf2, KLHL19
Species	Human
Gene Type	protein-coding
Description	kelch-like ECH-associated protein 1
Other Description	cytosolic inhibitor of Nrf2|kelch-like family member 19|kelch-like protein 19
Swissprots	Q8WTX1 B3KPD5 Q9BPY9 Q6LEP0 Q14145
Accessions	AAK43722 EAW84110 EAW84111 EAW84112 Q14145 AF361886 AAK51082 AK056204 BAG51647 AU130822 BC002417 AAH02417 BC002930 AAH02930 BC003156 BC014118 BC015945 AAH15945 BC021957 AAH21957 D50922 BAA09481 DQ893639 ABM84565 DQ895597 ABM86523 EU176209 ABW03660 XM_005260173 XP_005260230 XM_005260174 XP_005260231 XM_011528452 XP_011526754 NM_012289 NP_036421 NM_203500 NP_987096
Function	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:15379550}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Keap1 full length protein - ab132384 from Abcam Category Protein Source Wheat germ Species Human

Human Keap1 peptide - ab111654 from Abcam Category Peptide Species Human

Human Keap1 peptide - ab32770 from Abcam Category Peptide

KEAP1 Antibody Blocking Peptide - LS-E39 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KEAP1 Antibody Blocking Peptide - LS-E27701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KEAP1 Antibody Blocking Peptide - LS-E12358 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KEAP1 Antibody Blocking Peptide - LS-E31339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KEAP1 Antibody Blocking Peptide - LS-E14053 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Keap1 Protein - H00009817-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KEAP1-Antibody-C-term-Blocking-peptide - BP10092b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KEAP1-Antibody-C-term-Blocking-Peptide - BP10441b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human KEAP1 protein - orb139244 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human Cytosolic inhibitor of Nrf2 protein - orb84414 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Insect Species Human

Human KEAP1 protein (GST Tag) - orb139245 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

KEAP1 Blocking Peptide - 33R-9382 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KEAP1 Blocking Peptide - 33R-3861 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KEAP1 Blocking Peptide - 33R-8707 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KEAP1 Peptide - AC21-2517-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KEAP1 - H00009817-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KEAP1 - H00009817-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KEAP1 (C-term) Control Peptide - AP55471CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

KEAP1 Peptide - 7045P from ProSci Category Peptide Species Human

KEAP1 Peptide - 42-391P from ProSci Category Peptide Species Human, Mouse

KEAP1 fusion protein - ag16693 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

KEAP1 fusion protein - Ag0779 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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