SPOP

Gene Symbol	SPOP
Entrez Gene	8405
Alt Symbol	BTBD32, TEF2
Species	Human
Gene Type	protein-coding
Description	speckle-type POZ protein
Other Description	HIB homolog 1|roadkill homolog 1
Swissprots	B2R6S3 Q53HJ1 D3DTW7 O43791
Accessions	CAC39513 EAW94671 EAW94672 EAW94673 EAW94674 EAW94675 O43791 AJ000644 CAA04199 AK123385 AK222589 BAD96309 AK293045 BAF85734 AK293587 BAG57055 AK300616 BAG62309 AK303268 BAG64350 AK312691 BAG35570 AK316366 BAH14737 AM392588 CAL37466 AM392643 CAL37521 AM392731 CAL37609 AM393008 CAL37886 AM393567 CAL38444 AM393826 CAL38701 AW449169 BC001269 AAH01269 BC003385 AAH03385 BM693397 BQ226031 BX282325 CB992730 W84567 XM_005257723 XP_005257780 XM_005257724 XP_005257781 NM_001007226 NP_001007227 NM_001007227 NP_001007228 NM_001007228 NP_001007229 NM_001007229 NP_001007230 NM_001007230 NP_001007231 NM_003563 NP_003554
Function	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.
Subcellular Location	Nucleus. Nucleus speckle.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9414087}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Speckle Type POZ Protein, SPOP, Human, ELISA Kit - E-EL-H1045 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Mouse, ELISA Kit - E-EL-M1087 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Rabbit, ELISA Kit - E-EL-RB0187 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Chicken, ELISA Kit - E-EL-Ch1202 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Porcine, ELISA Kit - E-EL-P1195 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Sheep, ELISA Kit - E-EL-S0682 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Guinea Pig, ELISA Kit - E-EL-GP0422 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Speckle Type POZ Protein, SPOP, Monkey, ELISA Kit - E-EL-MK0195 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Speckle Type POZ Protein (SPOP), Human, CLIA Kit - SCM278Hu from ARP American Research Products Category CLIA Kit Prices $783.00 Sizes 96 t Sensitivity 0.052ng/mL Range 0.156-10ng/mL

Human SPOP ELISA Kit - HS0183 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine SPOP ELISA Kit - AS0183 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human SPOP(Speckle Type POZ Protein) ELISA Kit - E-EL-H1045 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

Speckle type POZ Protein, ELISA Kit - MBS729600 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle type POZ Protein, ELISA Kit - MBS7225493 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS041218 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS036118 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS028700 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-type POZ Protein, ELISA Kit - MBS752673 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS028452 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-type POZ Protein, ELISA Kit - MBS723259 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS046148 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-type POZ Protein, ELISA Kit - MBS748877 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS028513 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-Type Poz Protein, ELISA Kit - MBS011875 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Speckle-type POZ Protein, ELISA Kit - MBS732012 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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