SPOP

Gene Symbol	SPOP
Entrez Gene	8405
Alt Symbol	BTBD32, TEF2
Species	Human
Gene Type	protein-coding
Description	speckle-type POZ protein
Other Description	HIB homolog 1|roadkill homolog 1
Swissprots	B2R6S3 Q53HJ1 D3DTW7 O43791
Accessions	CAC39513 EAW94671 EAW94672 EAW94673 EAW94674 EAW94675 O43791 AJ000644 CAA04199 AK123385 AK222589 BAD96309 AK293045 BAF85734 AK293587 BAG57055 AK300616 BAG62309 AK303268 BAG64350 AK312691 BAG35570 AK316366 BAH14737 AM392588 CAL37466 AM392643 CAL37521 AM392731 CAL37609 AM393008 CAL37886 AM393567 CAL38444 AM393826 CAL38701 AW449169 BC001269 AAH01269 BC003385 AAH03385 BM693397 BQ226031 BX282325 CB992730 W84567 XM_005257723 XP_005257780 XM_005257724 XP_005257781 NM_001007226 NP_001007227 NM_001007227 NP_001007228 NM_001007228 NP_001007229 NM_001007229 NP_001007230 NM_001007230 NP_001007231 NM_003563 NP_003554
Function	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.
Subcellular Location	Nucleus. Nucleus speckle.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9414087}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPOP full length protein - ab75463 from Abcam Category Protein Source E. coli Species Human

Human SPOP full length protein - ab105599 from Abcam Category Protein Source E. coli Species Human

SPOP Antibody Blocking Peptide - LS-E6128 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPOP Recombinant Protein - H00008405-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

SPOP Partial Recombinant Protein - H00008405-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SPOP Protein - NBP1-51077 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

SPOP-Antibody-N-term-Blocking-Peptide - BP18747a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPOP Protein (OPPA00190) - OPPA00190 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

Human SPOP protein - orb169344 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

SPOP Blocking Peptide - 33R-10118 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SPOP protein (His tag) - 80R-1767 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

SPOP (1-347, His-tag) - AR09949PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

SPOP (1-347, His-tag) - AR09949PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

SPOP - H00008405-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SPOP - H00008405-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SPOP, 1-374aa, Human, His tag, E.coli - 01-P1009 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

SPOP fusion protein - Ag10384 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SPOP fusion protein - Ag1191 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SPOP fusion protein - Ag10215 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SPOP Human - PRPS-202 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SPOP Protein - BP002249-PRO-195 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

SPOP, 1-374aa, Recombinant Protein - GWB-P1029B from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

SPOP Human Protein - GWB-BSP676 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human Speckle-type POZ Protein, T7-tagged - SPOP-2992H from Creative Biomart Category Protein

Recombinant Human SPOP, His-tagged - SPOP-3506H from Creative Biomart Category Protein

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