SPOP

Gene Symbol SPOP
Entrez Gene 8405
Alt Symbol BTBD32, TEF2
Species Human
Gene Type protein-coding
Description speckle-type POZ protein
Other Description HIB homolog 1|roadkill homolog 1
Swissprots B2R6S3 Q53HJ1 D3DTW7 O43791
Accessions CAC39513 EAW94671 EAW94672 EAW94673 EAW94674 EAW94675 O43791 AJ000644 CAA04199 AK123385 AK222589 BAD96309 AK293045 BAF85734 AK293587 BAG57055 AK300616 BAG62309 AK303268 BAG64350 AK312691 BAG35570 AK316366 BAH14737 AM392588 CAL37466 AM392643 CAL37521 AM392731 CAL37609 AM393008 CAL37886 AM393567 CAL38444 AM393826 CAL38701 AW449169 BC001269 AAH01269 BC003385 AAH03385 BM693397 BQ226031 BX282325 CB992730 W84567 XM_005257723 XP_005257780 XM_005257724 XP_005257781 NM_001007226 NP_001007227 NM_001007227 NP_001007228 NM_001007228 NP_001007229 NM_001007229 NP_001007230 NM_001007230 NP_001007231 NM_003563 NP_003554
Function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.
Subcellular Location Nucleus. Nucleus speckle.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9414087}.

Human BTBD32 Gene - orb93574 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

SPOP - MBS1267634 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC001269

Human SPOP cDNA clone(NM_001007226.1) - CDFH018535 from Creative Biomart

Species Human
Accession NM_001007226.1

Human SPOP cDNA clone(NM_001007227.1) - CDFH018536 from Creative Biomart

Species Human
Accession NM_001007227.1

Human SPOP cDNA clone(NM_001007228.1) - CDFH018537 from Creative Biomart

Species Human
Accession NM_001007228.1

Human SPOP cDNA clone(NM_001007229.1) - CDFH018538 from Creative Biomart

Species Human
Accession NM_001007229.1

Human SPOP cDNA clone(NM_001007230.1) - CDFH018539 from Creative Biomart

Species Human
Accession NM_001007230.1

Human SPOP cDNA clone(NM_003563.3) - CDFH018540 from Creative Biomart

Species Human
Accession NM_003563.3

Human SPOP ORF clone(NM_003563.3) - CDCL186291 from Creative Biomart

Species Human
Accession NM_003563.3

human SPOP ORF clone - CDCH085528 from Creative Biomart

Species Human
Accession NM_001007226

human SPOP ORF clone - CDCH085529 from Creative Biomart

Species Human
Accession NM_001007226

Human SPOP ORF Clone(NM_003563.3) - CDCR285952 from Creative Biomart

Species Human
Accession NM_003563.3

Human SPOP ORF Clone(NM_003563.3) - CDCR285953 from Creative Biomart

Species Human
Accession NM_003563.3

Human SPOP ORF Clone(NM_003563.3) - CDCR285954 from Creative Biomart

Species Human
Accession NM_003563.3

Human SPOP ORF Clone(NM_001007226.1) - CDCR340191 from Creative Biomart

Species Human
Accession NM_001007226.1

Human SPOP ORF Clone(NM_001007226.1) - CDCR340192 from Creative Biomart

Species Human
Accession NM_001007226.1

Human SPOP ORF Clone(NM_001007227.1) - CDCR340193 from Creative Biomart

Species Human
Accession NM_001007227.1

Human SPOP ORF Clone(NM_001007227.1) - CDCR340194 from Creative Biomart

Species Human
Accession NM_001007227.1

Human SPOP ORF Clone(NM_001007228.1) - CDCR340195 from Creative Biomart

Species Human
Accession NM_001007228.1

Human SPOP ORF Clone(NM_001007228.1) - CDCR340196 from Creative Biomart

Species Human
Accession NM_001007228.1

Human SPOP ORF Clone(NM_001007229.1) - CDCR340197 from Creative Biomart

Species Human
Accession NM_001007229.1

Human SPOP ORF Clone(NM_001007229.1) - CDCR340198 from Creative Biomart

Species Human
Accession NM_001007229.1

Human SPOP ORF Clone(NM_001007230.1) - CDCR340199 from Creative Biomart

Species Human
Accession NM_001007230.1

Human SPOP ORF Clone(NM_001007230.1) - CDCR340200 from Creative Biomart

Species Human
Accession NM_001007230.1

Human SPOP Gene cDNA clone plasmid - HG13135-G from Sino Biological

Species Human
Search more