SPOP

Gene Symbol	SPOP
Entrez Gene	8405
Alt Symbol	BTBD32, TEF2
Species	Human
Gene Type	protein-coding
Description	speckle-type POZ protein
Other Description	HIB homolog 1|roadkill homolog 1
Swissprots	B2R6S3 Q53HJ1 D3DTW7 O43791
Accessions	CAC39513 EAW94671 EAW94672 EAW94673 EAW94674 EAW94675 O43791 AJ000644 CAA04199 AK123385 AK222589 BAD96309 AK293045 BAF85734 AK293587 BAG57055 AK300616 BAG62309 AK303268 BAG64350 AK312691 BAG35570 AK316366 BAH14737 AM392588 CAL37466 AM392643 CAL37521 AM392731 CAL37609 AM393008 CAL37886 AM393567 CAL38444 AM393826 CAL38701 AW449169 BC001269 AAH01269 BC003385 AAH03385 BM693397 BQ226031 BX282325 CB992730 W84567 XM_005257723 XP_005257780 XM_005257724 XP_005257781 NM_001007226 NP_001007227 NM_001007227 NP_001007228 NM_001007228 NP_001007229 NM_001007229 NP_001007230 NM_001007230 NP_001007231 NM_003563 NP_003554
Function	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.
Subcellular Location	Nucleus. Nucleus speckle.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9414087}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPOP 293T Cell Transient Overexpression Lysate(Denatured) - H00008405-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SPOP overexpression lysate - LY401186 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP overexpression lysate - LY423451 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP overexpression lysate - LY423453 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP overexpression lysate - LY423454 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP overexpression lysate - LY425207 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP overexpression lysate - LY425209 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SPOP 293 Cell Lysate - 401097 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SPOP 293 Cell Lysate - 409946 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBL1-16419 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBL1-16421 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBP2-08812 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBP2-08811 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBP2-09118 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP Overexpression Lysate (Native) - NBP2-09119 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SPOP (h3): 293 Lysate - sc-129835 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SPOP Over-expression Lysate Product - GWB-F5CAF6 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SPOP Over-expression Lysate Product - GWB-6B21A1 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SPOP Overexpression Lysate (Denatured) - H00008405-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SPOP Overexpression Lysate (Denatured) - H00008405-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SPOP Knockdown Stable Cell Line - CSC-DC015080 from Creative biogene Category Cell Line Species Human

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