LAMP3

Gene Symbol LAMP3
Entrez Gene 27074
Alt Symbol CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403
Species Human
Gene Type protein-coding
Description lysosomal-associated membrane protein 3
Other Description DC-lysosome-associated membrane glycoprotein|lysosome-associated membrane glycoprotein 3
Swissprots O94781 Q9UQV4 Q8NEC8 D3DNS4
Accessions CBX47465 EAW78337 EAW78338 Q9UQV4 AB013924 BAA34533 AJ005766 CAA06691 AK302894 BAG64067 AK313172 BAG35989 BC032940 AAH32940 BI462212 DA994656 DC399447 DQ892118 ABM83044 XM_005247360 XP_005247417 XM_006713586 XP_006713649 XM_011512688 XP_011510990 XR_924123 XR_924124 NM_014398 NP_055213
Function May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.
Subcellular Location Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.
Tissue Specificity Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9721848, ECO:0000269|PubMed:9768752}.
Top Pathways Lysosome

DC-LAMP (H-260) - sc-98657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DC-LAMP (H-260): sc-98657. Western blot analysis of DC-LAMP expression in 293T whole cell lysate.

DC-LAMP (T-20) - sc-83135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LAMP3 antibody - ab153932 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of methanol-fixed HeLa cells, labeling LAMP3 with ab153932 at 1/500 dilution. Lower image shows cells co-stained with Hoechst 33342.

Anti-LAMP3 antibody - ab83659 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LAMP3 antibody (ab83659) at 1 µg/ml (in 5% skim milk/ PBS) + MCF7 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-LAMP3 antibody - ab111090 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111090 at 1/50 dilution staining LAMP3 in paraffin-embedded Human Lung carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-LAMP3 antibody - ab167260 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-LAMP3 antibody (ab167260) at 1 µg/mlLane 1 : LAMP3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-LAMP3 antibody - N-terminal - ab173864 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of U251 cells labeling LAMP3 with ab173864 at 1/100 dilution.  U251 cells were treated with Chloroquine (50 μM,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1/1000 dilution). Nuclei were counterstained with Hoechst 33342 (blue) (10 μg/ml, 5 min). 

Anti-LAMP3 / CD208 Antibody (aa8-38, AP) - LS-C237007 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (clone 13A205) - LS-C183393 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 13A205

Anti-LAMP3 / CD208 Antibody (aa8-38, Biotin) - LS-C237009 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa8-38, PE) - LS-C237012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa8-38, APC) - LS-C237008 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa8-38, FITC) - LS-C237011 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa8-38, Azide-free, HRP) - LS-C248685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody - LS-C308707 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa16-45) - LS-C322581 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa36-85) - LS-C101921 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LAMP3 antibody LS-C101921 Western blot of MCF7 cell lysate.

Anti-LAMP3 / CD208 Antibody - LS-C341500 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody (aa8-38) - LS-C165682 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Fluorescent image of U251 cells stained with LAMP3 antibody. U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated LAMP3 primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LAMP3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.

Anti-LAMP3 / CD208 Antibody (aa274-323) IHC-plus™ - LS-B7698 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LAMP3 / CD208 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7698 dilution 10 ug/ml.

Anti-LAMP3 / CD208 Antibody - LS-C332274 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat brain tissue using LAMP3 antibody at dilution of 1:200 (x400 lens).

Anti-LAMP3 / CD208 Antibody (PE) - LS-C71901 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-LAMP3 / CD208 Antibody - LS-C37252 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

DC-LAMP Antibody (1010E1.01) - DDX0191P-100 from Novus Biologicals

Prices $329.00, $399.00
Sizes 50 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 1010E1.01
Immunohistochemistry: DC-LAMP Antibody (1010E1.01) [DDX0191P-100] - IHC on mouse lungcryosection

DC-LAMP Antibody (530217) [Unconjugated] - MAB4087 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 530217
Western blot shows lysates of in vitro differentiated human myeloid mature dendritic cells. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human DC-LAMP Monoclonal Antibody (Catalog # MAB4087) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for DC-LAMP at approximately 100 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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