| Gene Symbol |
LAMP3
|
| Entrez Gene |
27074
|
| Alt Symbol |
CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysosomal-associated membrane protein 3
|
| Other Description |
DC-lysosome-associated membrane glycoprotein|lysosome-associated membrane glycoprotein 3
|
| Swissprots |
O94781 Q9UQV4 Q8NEC8 D3DNS4
|
| Accessions |
CBX47465 EAW78337 EAW78338 Q9UQV4 AB013924 BAA34533 AJ005766 CAA06691 AK302894 BAG64067 AK313172 BAG35989 BC032940 AAH32940 BI462212 DA994656 DC399447 DQ892118 ABM83044 XM_005247360 XP_005247417 XM_006713586 XP_006713649 XM_011512688 XP_011510990 XR_924123 XR_924124 NM_014398 NP_055213
|
| Function |
May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.
|
| Subcellular Location |
Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.
|
| Tissue Specificity |
Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9721848, ECO:0000269|PubMed:9768752}.
|
| Top Pathways |
Lysosome
|
![Western Blot: LAMP3 Overexpression Lysate (Adult Normal) [NBL1-12432] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LAMP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8377_LAMP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12432-img0002.jpg)