FKBP1A

Gene Symbol FKBP1A
Entrez Gene 2280
Alt Symbol FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE
Species Human
Gene Type protein-coding
Description FK506 binding protein 1A, 12kDa
Other Description 12 kDa FK506-binding protein|12 kDa FKBP|FK506 binding protein12|FK506-binding protein 1|FK506-binding protein 12|FK506-binding protein 1A (12kD)|FK506-binding protein, T-cell, 12-kD|FKBP12-Exip3|PPIase FKBP1A|calstabin 1|calstabin-1|immunophilin FKBP12|peptidyl-prolyl cis-trans isomerase FKBP1A|protein kinase C inhibitor 2|rotamase
Swissprots Q6LEU3 Q9H103 Q6FGD9 P20071 D3DVW6 Q9H566 Q4VC47 P62942
Accessions AAA58472 AAA58476 BAE44301 CAA39272 CAI95951 EAX10633 EAX10634 EAX10635 P62942 AA731598 AB241123 BAE94235 AB241124 BAE94236 AB241125 BAE94237 AF205192 AAF17608 AI753994 BC001925 AAH01925 BC005147 AAH05147 BC119732 AAI19733 BC119733 AAI19734 BT007066 AAP35729 BU540706 CA450516 CN426120 CR407613 CAG28541 CR542168 CAG46965 CX870892 D28444 BAA05810 DQ891819 ABM82745 M34539 AAA35844 X52220 CAA36462 NM_000801 NP_000792 NM_001199786 NP_001186715 NM_054014 NP_463460
Function Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:9233797}.
Subcellular Location Cytoplasm.

FKBP12 (C-19) - sc-6173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FKBP12 (C-19): sc-6173. Western blot analysis of FKBP12 expression in non-transfected: sc-117752 (A) and mouse FKBP12 transfected: sc-126858 (B) 293T whole cell lysates.

FKBP12 (G-4) - sc-136962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FKBP12 (G-4): sc-136962. Western blot analysis of FKBP12 expression in non-transfected: sc-117752 (A) and mouse FKBP12 transfected: sc-126858 (B) 293T whole cell lysates.

FKBP12 (FL-108) - sc-28814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FKBP12 (FL-108): sc-28814. Western blot analysis of FKBP12 expression in non-transfected 293T: sc-117752 (A), mouse FKBP12 transfected 293T: sc-126858 (B) and human PBL (C) whole cell lysates.

FKBP12 (H-5) - sc-133067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FKBP12 (H-5): sc-133067. Western blot analysis of FKBP12 expression in non-transfected 293T: sc-117752 (A), mouse FKBP12 transfected 293T: sc-126858 (B) and human PBL (C) whole cell lysates.

FKBP12 (N-19) - sc-6174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FKBP12 (N-19): sc-6174. Western blot analysis of FKBP12 expression in U-937 (A) whole cell lysate and mouse brain (B) extract.

FKBP12 (8) - sc-135908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
FKBP12 (8): sc-135908. Western blot analysis of FKBP12 expression in SW-13 whole cell lysate.

FKBP12/12.6 (N-15) - sc-131521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FKBP12 antibody - ab2918 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab2918 at 1/1000 staining FKBP12 from human penis tissue by IHC-P. The tissue was paraformaldehyde fixed and the slides were incubated in citrate buffer for antigen retrieval and heated for 20 minutes. The tissue was incubated with ab2918 for 24 hours. The secondary antibody used was part of the DAKO ENVISON System. The picture depicts staining of nerve fibers within corporal tissue of the human penis.See Abreview

Anti-FKBP12 antibody - ab58072 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP12 antibody - ab24373 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FKBP12 antibody (ab24373) at 1 µg/mlLane 1 : Human Brain Tissue LysateLane 2 : Mouse Brain Tissue LysateLane 3 : Rat Brain Tissue LysateLysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-FKBP12 antibody - ab191844 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FKBP12 antibody (ab191844) at 1 µg/ml + A431 cell lysate at 15 µg

Anti-FKBP12 antibody - ab180758 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FKBP12 antibody (ab180758) at 1/500 dilution + Mouse cerebellum tissue extract

Anti-FKBP12 antibody - ab80006 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab80006, at a 1/10 dilution, staining FKBP12 in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. ab80006 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-FKBP12 antibody [EP3887] - ab108420 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3887
All lanes : Anti-FKBP12 antibody [EP3887] (ab108420) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : HL-60 brain lysateLane 3 : U937 lysateLane 4 : SH-SY5Y lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FKBP12 antibody [EPR3888] - ab92459 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3888
All lanes : Anti-FKBP12 antibody [EPR3888] (ab92459) at 1/10000 dilutionLane 1 : Fetal brain lysateLane 2 : U937 cell lysateLane 3 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-FKBP1A / FKBP12 Antibody (Biotin) - LS-C183186 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FKBP1A / FKBP12 Antibody (N-Terminus) - LS-C151908 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FKBP1A / FKBP12 antibody Western Blot of Placenta.

Anti-FKBP1A / FKBP12 Antibody (C-Terminus, clone EPR3888) - LS-C105744 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3888
Western blot analysis on (A) fetal brain, (B) U937 and (C) SH-SY5Y cell lysates using anti-FKBP12 antibody (LS-C105744).

Anti-FKBP1A / FKBP12 Antibody - LS-C48578 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of FKBP12 antibody LS-C48578.

Anti-FKBP1A / FKBP12 Antibody (aa20-69) - LS-C151907 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FKBP1A / FKBP12 antibody Western Blot of 721_B.

Anti-FKBP1A / FKBP12 Antibody - LS-C189981 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FKBP1A / FKBP12 Antibody (aa43-74) - LS-C96680 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FKBP12 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-FKBP1A / FKBP12 Antibody (aa1-13) IHC-plus™ - LS-B2265 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FKBP1A / FKBP12 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2265 concentration 5 ug/ml.

Anti-FKBP1A / FKBP12 Antibody (aa2-108, FITC) - LS-C303493 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-FKBP1A / FKBP12 Antibody (aa2-108, Biotin) - LS-C301146 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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