| Gene Symbol |
FEM1B
|
| Entrez Gene |
10116
|
| Alt Symbol |
F1A-ALPHA, F1AA, FEM1-beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fem-1 homolog b (C. elegans)
|
| Other Description |
FEM-1-like death receptor binding protein|fem-1-like death receptor-binding protein alpha|fem-1-like in apoptotic pathway protein alpha|protein fem-1 homolog B
|
| Swissprots |
Q9UK73 O43146
|
| Accessions |
EAW77818 EAW77819 Q9UK73 AB007856 BAA23692 AF178632 AAF05314 AF204883 AAF69303 AK098620 AK290167 BAF82856 AL833264 BC010122 AAH10122 BC014558 AAH14558 BF112021 CR626996 EU176451 ABW03902 XM_006720370 XP_006720433 NM_015322 NP_056137
|
| Function |
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. {ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19330022}. Nucleus {ECO:0000269|PubMed:19330022}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
|
| Tissue Specificity |
Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. {ECO:0000269|PubMed:10542291}.
|