Gene Symbol | FEM1B |
---|---|
Entrez Gene | 10116 |
Alt Symbol | F1A-ALPHA, F1AA, FEM1-beta |
Species | Human |
Gene Type | protein-coding |
Description | fem-1 homolog b (C. elegans) |
Other Description | FEM-1-like death receptor binding protein|fem-1-like death receptor-binding protein alpha|fem-1-like in apoptotic pathway protein alpha|protein fem-1 homolog B |
Swissprots | Q9UK73 O43146 |
Accessions | EAW77818 EAW77819 Q9UK73 AB007856 BAA23692 AF178632 AAF05314 AF204883 AAF69303 AK098620 AK290167 BAF82856 AL833264 BC010122 AAH10122 BC014558 AAH14558 BF112021 CR626996 EU176451 ABW03902 XM_006720370 XP_006720433 NM_015322 NP_056137 |
Function | Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. {ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19330022}. Nucleus {ECO:0000269|PubMed:19330022}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. |
Tissue Specificity | Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. {ECO:0000269|PubMed:10542291}. |