ENPP7

Gene Symbol	ENPP7
Entrez Gene	339221
Alt Symbol	ALK-SMase, E-NPP 7, NPP-7, NPP7
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 7
Other Description	alkaline sphingomyelin phosphodiesterase|alkaline sphingomyelinase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase
Swissprots	Q8IUS8 Q6ZTS5 Q6UWV6
Accessions	EAW89566 Q6UWV6 AK126250 BAC86504 AK128662 AY230663 AAP69661 AY358622 AAQ88985 BC041453 AAH41453 DB187443 XM_011524737 XP_011523039 NM_178543 NP_848638
Function	Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.
Subcellular Location	Membrane {ECO:0000269|PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Tissue Specificity	Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Top Pathways	Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ENPP7 ELISA Kit (Sandwich ELISA) - LS-F5652 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 1.39 ng/ml Range 0.156-10 ng/ml

Human Alk-Smase ELISA Kit - abx150616 from Abbexa Category ELISA Kit Sensitivity 1.39 ng/ml Range 3.125 ng/ml - 200 ng/ml

Alkaline Sphingomyelinase, Alk-Smase, Human, ELISA Kit - E-EL-H0311 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Alkaline Sphingomyelinase (Alk-Smase), Human, ELISA Kit - SEA801Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 1.39ng/mL Range 3.12-200ng/mL

Alkaline Sphingomyelinase, Human, ELISA Kit - E01A0403 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

Alkaline Sphingomyelinase, Alk-Smase, Rabbit, ELISA Kit - E-EL-RB0642 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Alkaline Sphingomyelinase, Alk-Smase, Chicken, ELISA Kit - E-EL-Ch1727 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Alkaline Sphingomyelinase, Alk-Smase, Porcine, ELISA Kit - E-EL-P1753 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Alkaline Sphingomyelinase, Alk-Smase, Sheep, ELISA Kit - E-EL-S0327 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Alkaline Sphingomyelinase, Alk-Smase, Monkey, ELISA Kit - E-EL-MK1211 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human alk-Smase ELISA Kit - HA0410 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine Alk-Smase ELISA Kit - AA0410 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

ectonucleotide pyrophosphatase/phosphodiesterase 7, ELISA Kit - MBS9317994 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Alk-Smase(Alkaline Sphingomyelinase) ELISA Kit - E-EL-H0311 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human Alk-Smase (Alkaline Sphingomyelinase) CLIA Kit - E-CL-H0251 from Elabscience Category CLIA Kit Sensitivity 46.88 pg/mL Range Average Recovery (%)

Alk-Smase, ELISA Kit - MBS2500925 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

Alkaline Sphingomyelinase, ELISA Kit - MBS062464 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Sphingomyelinase, ELISA Kit - MBS016650 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Sphingomyelinase, ELISA Kit - MBS061569 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Sphingomyelinase, ELISA Kit - MBS731850 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)

Alkaline Sphingomyelinase, ELISA Kit - MBS053971 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Sphingomyelinase, ELISA Kit - MBS039905 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 6.25 U/L ~ 200 U/L.

Alkaline Sphingomyelinase, ELISA Kit - MBS018675 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Sphingomyelinase, ELISA Kit - MBS100853 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.5ng/ml-16ng/ml.

Alkaline Sphingomyelinase (Alk-Smase), ELISA Kit - MBS2022748 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human Alk-Smase is typically less than 1.39ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 3.12-200ng/mL

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