ENPP7

Gene Symbol ENPP7
Entrez Gene 339221
Alt Symbol ALK-SMase, E-NPP 7, NPP-7, NPP7
Species Human
Gene Type protein-coding
Description ectonucleotide pyrophosphatase/phosphodiesterase 7
Other Description alkaline sphingomyelin phosphodiesterase|alkaline sphingomyelinase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase
Swissprots Q8IUS8 Q6ZTS5 Q6UWV6
Accessions EAW89566 Q6UWV6 AK126250 BAC86504 AK128662 AY230663 AAP69661 AY358622 AAQ88985 BC041453 AAH41453 DB187443 XM_011524737 XP_011523039 NM_178543 NP_848638
Function Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.
Subcellular Location Membrane {ECO:0000269|PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Tissue Specificity Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Top Pathways Sphingolipid metabolism

Alk-SMase CRISPR/Cas9 KO Plasmid (h) - sc-415505 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase HDR Plasmid (h) - sc-415505-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase Double Nickase Plasmid (h) - sc-415505-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase Double Nickase Plasmid (h2) - sc-415505-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase CRISPR Activation Plasmid (h) - sc-415505-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase CRISPR Activation Plasmid (h2) - sc-415505-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase Lentiviral Activation Particles (h) - sc-415505-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase Lentiviral Activation Particles (h2) - sc-415505-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Alk-SMase siRNA (h) - sc-60151 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Alk-SMase shRNA Plasmid (h) - sc-60151-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Alk-SMase shRNA (h) Lentiviral Particles - sc-60151-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® Human Phosphatase - SIHP0179 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0180 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0178 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN7886 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7886 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03733 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03733

ENPP7 siRNA (Human) - CRJ7274 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ENPP7 - MBS8219845 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ENPP7 (NM_178543.3) - SHH285985 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ENPP7(NM_178543.3) - SHH034337 from Creative biogene

Category siRNA
Species Reactivities Human

Human ENPP7 siRNA - orb277775 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ENPP7 shRNA Plasmid (Human) - CHJ7274 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ENPP7 miRNA 3'UTR clone - MiUTR1H-03232 from Creative biogene

Species Reactivities Human
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