Gene Symbol | ENPP7 |
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Entrez Gene | 339221 |
Alt Symbol | ALK-SMase, E-NPP 7, NPP-7, NPP7 |
Species | Human |
Gene Type | protein-coding |
Description | ectonucleotide pyrophosphatase/phosphodiesterase 7 |
Other Description | alkaline sphingomyelin phosphodiesterase|alkaline sphingomyelinase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase |
Swissprots | Q8IUS8 Q6ZTS5 Q6UWV6 |
Accessions | EAW89566 Q6UWV6 AK126250 BAC86504 AK128662 AY230663 AAP69661 AY358622 AAQ88985 BC041453 AAH41453 DB187443 XM_011524737 XP_011523039 NM_178543 NP_848638 |
Function | Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}. |
Tissue Specificity | Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}. |
Top Pathways | Sphingolipid metabolism |
Alk-SMase CRISPR/Cas9 KO Plasmid (h) - sc-415505 from Santa Cruz Biotechnology
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Alk-SMase HDR Plasmid (h) - sc-415505-HDR from Santa Cruz Biotechnology
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Alk-SMase Double Nickase Plasmid (h) - sc-415505-NIC from Santa Cruz Biotechnology
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Alk-SMase Double Nickase Plasmid (h2) - sc-415505-NIC-2 from Santa Cruz Biotechnology
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Alk-SMase CRISPR Activation Plasmid (h) - sc-415505-ACT from Santa Cruz Biotechnology
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Alk-SMase CRISPR Activation Plasmid (h2) - sc-415505-ACT-2 from Santa Cruz Biotechnology
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Alk-SMase Lentiviral Activation Particles (h) - sc-415505-LAC from Santa Cruz Biotechnology
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Alk-SMase Lentiviral Activation Particles (h2) - sc-415505-LAC-2 from Santa Cruz Biotechnology
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Alk-SMase siRNA (h) - sc-60151 from Santa Cruz Biotechnology
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Alk-SMase shRNA Plasmid (h) - sc-60151-SH from Santa Cruz Biotechnology
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Alk-SMase shRNA (h) Lentiviral Particles - sc-60151-V from Santa Cruz Biotechnology
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MISSION® Human Phosphatase - SIHP0179 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0180 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0178 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7886 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7886 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03733 from Sigma-Aldrich
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ENPP7 siRNA (Human) - CRJ7274 from Cohesion Biosciences
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ENPP7 - MBS8219845 from MyBioSource
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shRNA set against Human ENPP7 (NM_178543.3) - SHH285985 from Creative biogene
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shRNA set against Human ENPP7(NM_178543.3) - SHH034337 from Creative biogene
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Human ENPP7 siRNA - orb277775 from Biorbyt
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ENPP7 shRNA Plasmid (Human) - CHJ7274 from Cohesion Biosciences
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ENPP7 miRNA 3'UTR clone - MiUTR1H-03232 from Creative biogene
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