ENPP7

Gene Symbol ENPP7
Entrez Gene 339221
Alt Symbol ALK-SMase, E-NPP 7, NPP-7, NPP7
Species Human
Gene Type protein-coding
Description ectonucleotide pyrophosphatase/phosphodiesterase 7
Other Description alkaline sphingomyelin phosphodiesterase|alkaline sphingomyelinase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase
Swissprots Q8IUS8 Q6ZTS5 Q6UWV6
Accessions EAW89566 Q6UWV6 AK126250 BAC86504 AK128662 AY230663 AAP69661 AY358622 AAQ88985 BC041453 AAH41453 DB187443 XM_011524737 XP_011523039 NM_178543 NP_848638
Function Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.
Subcellular Location Membrane {ECO:0000269|PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Tissue Specificity Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Top Pathways Sphingolipid metabolism

ENPP7 293T Cell Transient Overexpression Lysate(Denatured) - H00339221-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

ENPP-7/Alk-SMase Overexpression Lysate (Denatured) - H00339221-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Human ENPP7 / NPP-7 HEK293 Cell Lysate (WB positive control) - 10885-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human ENPP7 Human Cells Transfected Lysate (positive control) (denatured) - orb173139 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human ENPP7 Knockdown Stable Cell Line - CSC-DC004951 from Creative biogene

Category Cell Line
Species Human
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