BMX

Gene Symbol	BMX
Entrez Gene	660
Alt Symbol	ETK, PSCTK2, PSCTK3
Species	Human
Gene Type	protein-coding
Description	BMX non-receptor tyrosine kinase
Other Description	BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|cytoplasmic tyrosine-protein kinase BMX|epithelial and endothelial tyrosine kinase
Swissprots	O60564 P51813 Q12871 A6NIH9
Accessions	EAW98889 EAW98890 P51813 AF045459 AAC08966 AK291824 BAF84513 AK313568 BAG36341 BC016652 AAH16652 BP236451 BQ226991 CB998198 DQ891059 ABM81985 DQ896814 ABM87813 U08341 AAA17744 X83107 CAA58169 XM_006724510 XP_006724573 NM_001721 NP_001712 NM_203281 NP_975010
Function	Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Tissue Specificity	Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BMX overexpression lysate - LY400648 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BMX overexpression lysate - LY404365 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BMX overexpression lysate - LY430904 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

BMX 293 Cell Lysate - 400638 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

BMX Overexpression Lysate (Native) - NBL1-08010 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BMX Overexpression Lysate (Native) - NBP2-04569 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Bmx (h): 293T Lysate - sc-113287 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Bmx (h2): 293T Lysate - sc-159692 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Bmx (h3): 293T Lysate - sc-170535 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

BMX Over-expression Lysate Product - GWB-603D44 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

BMX Overexpression Lysate (Native) - NBP2-10119 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human BMX Knockdown Stable Cell Line - CSC-DC001483 from Creative biogene Category Cell Line Species Human

Search more