BMX
| Gene Symbol | BMX |
|---|---|
| Entrez Gene | 660 |
| Alt Symbol | ETK, PSCTK2, PSCTK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BMX non-receptor tyrosine kinase |
| Other Description | BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|cytoplasmic tyrosine-protein kinase BMX|epithelial and endothelial tyrosine kinase |
| Swissprots | O60564 P51813 Q12871 A6NIH9 |
| Accessions | EAW98889 EAW98890 P51813 AF045459 AAC08966 AK291824 BAF84513 AK313568 BAG36341 BC016652 AAH16652 BP236451 BQ226991 CB998198 DQ891059 ABM81985 DQ896814 ABM87813 U08341 AAA17744 X83107 CAA58169 XM_006724510 XP_006724573 NM_001721 NP_001712 NM_203281 NP_975010 |
| Function | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1. |
| Tissue Specificity | Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. |
Bmx CRISPR/Cas9 KO Plasmid (h) - sc-401550 from Santa Cruz Biotechnology
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Bmx HDR Plasmid (h) - sc-401550-HDR from Santa Cruz Biotechnology
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Bmx Double Nickase Plasmid (h) - sc-401550-NIC from Santa Cruz Biotechnology
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Bmx Double Nickase Plasmid (h2) - sc-401550-NIC-2 from Santa Cruz Biotechnology
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Bmx CRISPR Activation Plasmid (h) - sc-401550-ACT from Santa Cruz Biotechnology
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Bmx CRISPR Activation Plasmid (h2) - sc-401550-ACT-2 from Santa Cruz Biotechnology
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Bmx Lentiviral Activation Particles (h) - sc-401550-LAC from Santa Cruz Biotechnology
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Bmx Lentiviral Activation Particles (h2) - sc-401550-LAC-2 from Santa Cruz Biotechnology
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Bmx siRNA (h) - sc-38941 from Santa Cruz Biotechnology
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Bmx shRNA Plasmid (h) - sc-38941-SH from Santa Cruz Biotechnology
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Bmx shRNA (h) Lentiviral Particles - sc-38941-V from Santa Cruz Biotechnology
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BMX RNAi - H00000660-R04 from Novus Biologicals
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BMX RNAi - H00000660-R03 from Novus Biologicals
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MISSION® esiRNA - EHU066711 from Sigma-Aldrich
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MISSION® siRNA - SIHK0179 from Sigma-Aldrich
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MISSION® siRNA - SIHK0180 from Sigma-Aldrich
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MISSION® siRNA - SIHK0181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2583 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2583 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03359 from Sigma-Aldrich
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BMX siRNA (Human) - CRH0455 from Cohesion Biosciences
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BMX - MBS8215654 from MyBioSource
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shRNA set against Human BMX (NM_001721.6) - SHH247206 from Creative biogene
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Human BMX siRNA - orb260957 from Biorbyt
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BMX shRNA Plasmid (Human) - CHH0455 from Cohesion Biosciences
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