BMX

Gene Symbol BMX
Entrez Gene 660
Alt Symbol ETK, PSCTK2, PSCTK3
Species Human
Gene Type protein-coding
Description BMX non-receptor tyrosine kinase
Other Description BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|cytoplasmic tyrosine-protein kinase BMX|epithelial and endothelial tyrosine kinase
Swissprots O60564 P51813 Q12871 A6NIH9
Accessions EAW98889 EAW98890 P51813 AF045459 AAC08966 AK291824 BAF84513 AK313568 BAG36341 BC016652 AAH16652 BP236451 BQ226991 CB998198 DQ891059 ABM81985 DQ896814 ABM87813 U08341 AAA17744 X83107 CAA58169 XM_006724510 XP_006724573 NM_001721 NP_001712 NM_203281 NP_975010
Function Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Tissue Specificity Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

Phospho-Etk (Tyr40) Antibody - 3211 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated (-) or anti-CD3 antibody-treated (+), using Phospho-Etk (Tyr40) Antibody (upper) or Etk Antibody #3212 (lower).

Etk/BMX Antibody - 14162 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from H526 and SK-MEL-2 cells using Etk/BMX Antibody.

Etk Antibody - 3212 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Bmx (C-4) - sc-376686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bmx (C-4): sc-376686. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (H-220) - sc-20711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bmx (H-220): sc-20711. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (D-6) - sc-271706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bmx (D-6): sc-271706. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (E-2) - sc-271025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bmx (E-2): sc-271025. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (N-16) - sc-8873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bmx (N-16): sc-8873. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (C-17) - sc-8874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bmx (C-17): sc-8874. Western blot analysis of Bmx expression in non-transfected: sc-117752 (A) and human Bmx transfected: sc-113287 (B) 293T whole cell lysates.

Bmx (40) - sc-136215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Bmx (40): sc-136215. Western blot analysis of Bmx expression in Jurkat whole cell lysate.

Anti-BMX (phospho Y40) antibody - ab59304 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab59304 at 1/50-1/100 dilution staining human skin tissue without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-BMX (phospho Y566) antibody - ab59409 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human thyroid gland tissue using ab59409 at a 1/50 dilution, in the presence (right) and absence (left) of immunizing phosphopeptide.

Anti-BMX (phospho Y566) antibody - ab195845 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BMX (phospho Y566) antibody (ab195845) at 1/500 dilutionLane 1 : Serum treated HeLa whole cell lysates with antigen-specific peptideLane 2 : Serum treated HeLa whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-BMX antibody - ab73887 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BMX antibody (ab73887) at 1/500 dilutionLane 1 : extracts from COS7 cellsLane 2 : extracts from COS7 cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-BMX antibody - ab59360 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BMX antibody (ab59360) at 1/500 dilutionLane 1 : Extracts from A549 cells with no immunizing peptideLane 2 : Extracts from A549 cells with immunizing peptideObserved band size : 78 kDa (why is the actual band size different from the predicted?)

Anti-BMX antibody - ab59288 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab59288 stained DU145 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum) / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab59288 at 5 µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BMX antibody - ab24515 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BMX antibody [1C6] - ab98950 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1C6
Anti-BMX antibody [1C6] (ab98950) at 1/500 dilution + BMX-transfected HEK293 cell lysate

Anti-BMX antibody [Y396] - ab32153 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y396
Anti-BMX antibody [Y396] (ab32153) at 1/500 dilution + HeLa cell lysate

Anti-ETK / BMX Antibody (Lys35) - LS-C176412 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of ETK (K35) pAb in paraffin-embedded human skin tissue.

Anti-ETK / BMX Antibody (Tyr43) - LS-C177060 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of Bmx (Y43) pAb in paraffin-embedded human thyroid gland tissue.

Anti-ETK / BMX Antibody (clone 3G3) - LS-C196765 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G3
Western Blot analysis of BMX expression in transfected 293T cell line by BMX monoclonal antibody (M01), clone 3G3.Lane 1: BMX transfected lysate (Predicted MW: 78.011 KDa).Lane 2: Non-transfected lysate.

Anti-ETK / BMX Antibody (phospho-Tyr40) - LS-C23306 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ETK / BMX Antibody - LS-C48381 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ETK / BMX Antibody (PH Domain, clone Y396) - LS-C49567 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y396
Western blot analysis on Hela cell lysate using anti-Etk/Bmx antibody, 1:500 dilution
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