BMX

Gene Symbol	BMX
Entrez Gene	660
Alt Symbol	ETK, PSCTK2, PSCTK3
Species	Human
Gene Type	protein-coding
Description	BMX non-receptor tyrosine kinase
Other Description	BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|cytoplasmic tyrosine-protein kinase BMX|epithelial and endothelial tyrosine kinase
Swissprots	O60564 P51813 Q12871 A6NIH9
Accessions	EAW98889 EAW98890 P51813 AF045459 AAC08966 AK291824 BAF84513 AK313568 BAG36341 BC016652 AAH16652 BP236451 BQ226991 CB998198 DQ891059 ABM81985 DQ896814 ABM87813 U08341 AAA17744 X83107 CAA58169 XM_006724510 XP_006724573 NM_001721 NP_001712 NM_203281 NP_975010
Function	Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Tissue Specificity	Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BMX full length protein - ab60877 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human BMX protein fragment - ab152238 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ETK / BMX Antibody Blocking Peptide - LS-E9206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BMX Peptide - NBP1-45548PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg Species Human, Mouse, Rat

BMX Partial Recombinant Protein - H00000660-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BMX Recombinant Protein - P4216 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human BMX Protein - P3842 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

Recombinant BMX Protein - NBP1-99469 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

BMX Peptide - P2743 from Novus Biologicals Category Peptide Species Human

BMX-Antibody-Center-Blocking-Peptide - BP7698c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BMX (Active) recombinant protein - GTX65022 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

BMX Blocking Peptide - 33R-10742 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BMX Blocking Peptide - 33R-10743 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BMX protein - 30R-2847 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

Etk/BMX Blocking Peptide - 33R-10483 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

BMX (phospho-Tyr40) Blocking Peptide - abx062296 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

BMX Blocking Peptide - abx161307 from Abbexa Category Peptide Species Human, Mouse, Rat

BMX - H00000660-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BMX - H00000660-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BMX - P3842 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

BMX - P4216 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

BMX fusion protein - Ag3440 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human BMX Non-receptor Tyrosine Kinase, Active - BMX-654H from Creative Biomart Category Protein Source Escherichia coli.

Recombinant Human BMX, GST-tagged, Active - BMX-251H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human BMX - BMX-26755TH from Creative Biomart Category Protein

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