BMX

Gene Symbol	BMX
Entrez Gene	660
Alt Symbol	ETK, PSCTK2, PSCTK3
Species	Human
Gene Type	protein-coding
Description	BMX non-receptor tyrosine kinase
Other Description	BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|cytoplasmic tyrosine-protein kinase BMX|epithelial and endothelial tyrosine kinase
Swissprots	O60564 P51813 Q12871 A6NIH9
Accessions	EAW98889 EAW98890 P51813 AF045459 AAC08966 AK291824 BAF84513 AK313568 BAG36341 BC016652 AAH16652 BP236451 BQ226991 CB998198 DQ891059 ABM81985 DQ896814 ABM87813 U08341 AAA17744 X83107 CAA58169 XM_006724510 XP_006724573 NM_001721 NP_001712 NM_203281 NP_975010
Function	Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Tissue Specificity	Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BMX - MBS1275354 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016652

Human BMX transcript variant 2 Gene ORF cDNA clone in cloning vector - HG11394-M from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11394-M-F from Sino Biological Species Human

BMX - CL01257H01 from Elabscience Species Human Accession NM_001721.6

BMX - CL01257H02 from Elabscience Species Human Accession NM_203281.2

Human BMX ORF clone(NM_001721.6) - CDCL182904 from Creative biogene Species Human

Human BMX ORF Clone (BC016652) - CDCS410396 from Creative biogene Species Human Accession P51813

Human BMX gene - orb91887 from Biorbyt Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11394-NM from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11394-NH from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11394-CM from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11394-NF from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11394-ACR from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11394-ANR from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid - HG11394-UT from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11394-NY from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11394-ACG from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11394-CY from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11394-ANG from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11394-CF from Sino Biological Species Human

Human BMX transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11394-CH from Sino Biological Species Human

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