DLX5

Gene Symbol	DLX5
Entrez Gene	1749
Alt Symbol	SHFM1D
Species	Human
Gene Type	protein-coding
Description	distal-less homeobox 5
Other Description	distal-less homeo box 5|homeobox protein DLX-5|split hand/foot malformation type 1 with sensorineural hearing loss
Swissprots	B7Z4P3 Q9UPL1 P56178
Accessions	AAC17833 EAL24121 EAW76741 P56178 AA129308 AK023493 BAB14587 AK297614 BAH12629 BC006226 AAH06226 BT006903 AAP35549 DB280023 XM_005250185 XP_005250242 XM_011515860 XP_011514162 XR_927389 NM_005221 NP_005212
Function	Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:19497851}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dlx-5 (H-4) - sc-398150 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Dlx-5 (C-20) - sc-18152 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dlx-5 (Y-20) - sc-18151 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Dlx5 antibody - ab64827 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Dlx5 antibody - ab85997 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Dlx5 antibody - ab54729 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Dlx5 antibody [EPR4488] - ab109737 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4488

Anti-DLX5 Antibody (aa100-128) - LS-C167447 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa29-45) - LS-C6400 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa1-10) - LS-C125733 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DLX5 Antibody (C-Terminus) - LS-C30701 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa216-289) - LS-C184222 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128, APC) - LS-C256134 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128, AP) - LS-C256133 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (clone 1B7) - LS-C104935 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1B7

Anti-DLX5 Antibody (aa99-128, Biotin) - LS-C256135 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128, Azide-free, HRP) - LS-C256137 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128, FITC) - LS-C256136 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128, PE) - LS-C256138 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody - LS-C307262 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-DLX5 Antibody (aa120-169) - LS-C80030 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (aa99-128) - LS-C320858 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (Internal, clone EPR4488) - LS-C138127 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4488

Anti-DLX5 Antibody (N-Terminus) - LS-C80220 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DLX5 Antibody (Glu126) - LS-C176786 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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