| Gene Symbol |
DLX5
|
| Entrez Gene |
1749
|
| Alt Symbol |
SHFM1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
distal-less homeobox 5
|
| Other Description |
distal-less homeo box 5|homeobox protein DLX-5|split hand/foot malformation type 1 with sensorineural hearing loss
|
| Swissprots |
B7Z4P3 Q9UPL1 P56178
|
| Accessions |
AAC17833 EAL24121 EAW76741 P56178 AA129308 AK023493 BAB14587 AK297614 BAH12629 BC006226 AAH06226 BT006903 AAP35549 DB280023 XM_005250185 XP_005250242 XM_011515860 XP_011514162 XR_927389 NM_005221 NP_005212
|
| Function |
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:19497851}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: Dlx5 Overexpression Lysate (Adult Normal) [NBL1-09921] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dlx5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3227_Dlx5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09921-img0002.jpg)