IMPDH2

Gene Symbol IMPDH2
Entrez Gene 3615
Alt Symbol IMPD2, IMPDH-II
Species Human
Gene Type protein-coding
Description IMP (inosine 5'-monophosphate) dehydrogenase 2
Other Description IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
Swissprots P12268 Q6LEF3
Accessions AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways Purine metabolism, Drug metabolism - other enzymes

Anti-IMPDH2 antibody - ab85702 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-IMPDH2 antibody (ab85702) at 1 µg/ml + Human Skeletal Muscle lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-IMPDH2 antibody - ab70045 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IMPDH2 antibody (ab70045) at 1/500 dilutionLane 1 : IMPDH2-transfected 293T cell line lysateLane 2 : non-transfected 293T cell line lysate

Anti-IMPDH2 antibody [EPR8364(B)] - ab131158 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8364(B)
All lanes : Anti-IMPDH2 antibody [EPR8364(B)] (ab131158) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HepG2 cell lysate Lane 3 : HeLa cell lysateLane 4 : NCI-H460 cell lysateLysates/proteins at 10 per lane.

Anti-IMPDH2 antibody [EPR8364(B)] (Alexa Fluor® 488) - ab200770 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8364(B)
ab200770 staining IMPDH2 in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200770 at a 1/250 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-IMPDH2 antibody [EPR8364(B)] (Alexa Fluor® 647) - ab200775 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8364(B)
ab200775 staining IMPDH2 in HeLa cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200775 at a 1/250 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-IMPDH2 antibody [EPR8365(B)] - ab129165 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8365(B)
Overlay histogram showing K562 cells stained with ab129165 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab129165, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-IMPDH2 Antibody (aa167-178) - LS-C112727 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
IMPDH2 antibody (1 ug/ml) staining of Human Skeletal Muscle lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-IMPDH2 Antibody (C-Terminus) - LS-C81854 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-IMPDH2 Antibody (N-Terminus) - LS-C116573 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IMPDH2 antibody LS-C116573 Western blot of 721_B cell lysate.

Anti-IMPDH2 Antibody - LS-C308490 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IMPDH2 Antibody - LS-C211097 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 56.5 kDa. Observed band size: 56.5 kDa Additional bands at: 50 kDa, 70 kDa; We are unsure as to the identity of these extra bands.

Anti-IMPDH2 Antibody - LS-C311283 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IMPDH2 Antibody (FITC) - LS-C211099 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 56.5 kDa. Observed band size: 56.5 kDa Additional bands at: 50 kDa, 70 kDa; We are unsure as to the identity of these extra bands.

Anti-IMPDH2 Antibody - LS-C341584 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IMPDH2 Antibody (Biotin) - LS-C211100 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 56.5 kDa. Observed band size: 56.5 kDa Additional bands at: 50 kDa, 70 kDa; We are unsure as to the identity of these extra bands.

Anti-IMPDH2 Antibody (HRP) - LS-C211098 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 56.5 kDa. Observed band size: 56.5 kDa Additional bands at: 50 kDa, 70 kDa; We are unsure as to the identity of these extra bands.

Anti-IMPDH2 Antibody (Internal, clone EPR8364(B)) - LS-C154540 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8364(B)
IHC of paraffin-embedded human colon tissue using anti-IMPDH2 antibody.

Anti-IMPDH2 Antibody (aa180-210) - LS-C100583 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IMPDH2 Antibody IHC of formalin-fixed and paraffin-embedded human Lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IMPDH2 Antibody (C-Terminus, clone EPR8365(B)) - LS-C154414 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8365(B)
IHC of paraffin-embedded breast carcinoma tissue using anti-IMPDH2 antibody.

Anti-IMPDH2 Antibody (clone 1E12-B6) - LS-C197533 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E12-B6
Western Blot analysis of IMPDH2 expression in transfected 293T cell line by IMPDH2 monoclonal antibody (M01), clone 1E12-B6.Lane 1: IMPDH2 transfected lysate(55.8 KDa).Lane 2: Non-transfected lysate.

Anti-IMPDH2 Antibody - LS-C334000 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using IMPDH2 antibody.

IMP Dehydrogenase 2/IMPDH2 Antibody - NBP2-27195 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP2-27195] - Analysis of IMPDH using IMPDH antibody. Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide probed with 2 ug/ml of IMPDH antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

IMP Dehydrogenase 2/IMPDH2 Antibody - NBP2-27069 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP2-27069] - Analysis of IMPDH2 using IMPDH2 antibody. Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) 3T3 lysate probed with 2 ug/ml of IMPDH2 antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

IMP Dehydrogenase 2/IMPDH2 Antibody - NBP1-86177 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP1-86177] - Analysis in human cell line U-251 MG.

IMP Dehydrogenase 2/IMPDH2 Antibody - NBP1-32093 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP1-32093] - Sample(30 ug of whole cell lysate)A:H12997. 5% SDS PAGE, antibody diluted at 1:500.
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