IMPDH2

Gene Symbol IMPDH2
Entrez Gene 3615
Alt Symbol IMPD2, IMPDH-II
Species Human
Gene Type protein-coding
Description IMP (inosine 5'-monophosphate) dehydrogenase 2
Other Description IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
Swissprots P12268 Q6LEF3
Accessions AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways Purine metabolism, Drug metabolism - other enzymes

IMPDH2 CRISPR/Cas9 KO Plasmid (h) - sc-410835 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 HDR Plasmid (h) - sc-410835-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 Double Nickase Plasmid (h) - sc-410835-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 Double Nickase Plasmid (h2) - sc-410835-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 CRISPR Activation Plasmid (h) - sc-410835-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 CRISPR Activation Plasmid (h2) - sc-410835-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 Lentiviral Activation Particles (h) - sc-410835-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 Lentiviral Activation Particles (h2) - sc-410835-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPDH2 siRNA (h) - sc-105573 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMPDH2 shRNA Plasmid (h) - sc-105573-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMPDH2 shRNA (h) Lentiviral Particles - sc-105573-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: IMP Dehydrogenase 2/IMPDH2 RNAi [H00003615-R01V] - Analysis of IMPDH2 over-expressed 293 cell line, cotransfected with IMPDH2 Validated Chimera RNAi or non-transfected control. Blot probed with H00003615-M01. GAPDH (36.1 kDa) used as loading control.

IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU027541 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10660 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10660 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IMPDH2 siRNA (Human) - CRH2421 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IMPDH2 - MBS8222348 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IMPDH2 (NM_000884.2) - SHH319361 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IMPDH2(NM_000884.2) - SHL177204 from Creative biogene

Category siRNA
Species Reactivities Human

Human IMPDH2 siRNA - orb262923 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IMPDH2 shRNA Plasmid (Human) - CHH2421 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IMPDH2 miRNA 3'UTR clone - MiUTR1H-04938 from Creative biogene

Species Reactivities Human
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