Gene Symbol | IMPDH2 |
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Entrez Gene | 3615 |
Alt Symbol | IMPD2, IMPDH-II |
Species | Human |
Gene Type | protein-coding |
Description | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
Other Description | IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2 |
Swissprots | P12268 Q6LEF3 |
Accessions | AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875 |
Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}. |
Tissue Specificity | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
Top Pathways | Purine metabolism, Drug metabolism - other enzymes |
IMPDH2 CRISPR/Cas9 KO Plasmid (h) - sc-410835 from Santa Cruz Biotechnology
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IMPDH2 HDR Plasmid (h) - sc-410835-HDR from Santa Cruz Biotechnology
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IMPDH2 Double Nickase Plasmid (h) - sc-410835-NIC from Santa Cruz Biotechnology
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IMPDH2 Double Nickase Plasmid (h2) - sc-410835-NIC-2 from Santa Cruz Biotechnology
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IMPDH2 CRISPR Activation Plasmid (h) - sc-410835-ACT from Santa Cruz Biotechnology
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IMPDH2 CRISPR Activation Plasmid (h2) - sc-410835-ACT-2 from Santa Cruz Biotechnology
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IMPDH2 Lentiviral Activation Particles (h) - sc-410835-LAC from Santa Cruz Biotechnology
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IMPDH2 Lentiviral Activation Particles (h2) - sc-410835-LAC-2 from Santa Cruz Biotechnology
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IMPDH2 siRNA (h) - sc-105573 from Santa Cruz Biotechnology
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IMPDH2 shRNA Plasmid (h) - sc-105573-SH from Santa Cruz Biotechnology
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IMPDH2 shRNA (h) Lentiviral Particles - sc-105573-V from Santa Cruz Biotechnology
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IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01V from Novus Biologicals
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IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01 from Novus Biologicals
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MISSION® esiRNA - EHU027541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10660 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10660 from Sigma-Aldrich
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IMPDH2 siRNA (Human) - CRH2421 from Cohesion Biosciences
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IMPDH2 - MBS8222348 from MyBioSource
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shRNA set against Human IMPDH2 (NM_000884.2) - SHH319361 from Creative biogene
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shRNA set against Human IMPDH2(NM_000884.2) - SHL177204 from Creative biogene
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Human IMPDH2 siRNA - orb262923 from Biorbyt
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IMPDH2 shRNA Plasmid (Human) - CHH2421 from Cohesion Biosciences
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IMPDH2 miRNA 3'UTR clone - MiUTR1H-04938 from Creative biogene
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