IMPDH2

Gene Symbol	IMPDH2
Entrez Gene	3615
Alt Symbol	IMPD2, IMPDH-II
Species	Human
Gene Type	protein-coding
Description	IMP (inosine 5'-monophosphate) dehydrogenase 2
Other Description	IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
Swissprots	P12268 Q6LEF3
Accessions	AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity	IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IMPDH2 full length protein - ab113608 from Abcam Category Protein Source E. coli Species Human

Human IMPDH2 full length protein - ab185401 from Abcam Category Protein Source E. coli Species Human

IMPDH2 Antibody Blocking Peptide - LS-E19559 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IMPDH2 Antibody Blocking Peptide - LS-E19560 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IMPDH2 Antibody Blocking Peptide - LS-E8917 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IMPDH2 Antibody Blocking Peptide - LS-E26903 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein - H00003615-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein - NBP1-72513 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

IMPDH2-Antibody-Center-Blocking-Peptide - BP7390c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IMPDH2 blocking peptide - GTX88543-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant human Inosine-5'-monophosphate dehydrogenase 2 (OPCA00374) - OPCA00374 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human IMPDH2 protein - orb168658 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human IMPD2 protein - orb246671 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human IMPDH2 protein - orb180295 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

IMPDH2 Blocking Peptide - 33R-8336 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IMPDH2 Blocking Peptide - 33R-5627 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IMPDH2 protein (His tag) - 80R-2027 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

IMPDH2 Peptide - AC21-1735-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

IMPDH2 (1-514, His-tag) - AR50099PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

IMPDH2 (1-514, His-tag) - AR50099PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

IMPDH2 - H00003615-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IMPDH2 - H00003615-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IMPDH2, 1-514aa, Human, His tag, E.coli - 01-P1274 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

IMPDH2 Peptide - 46-966P from ProSci Category Peptide Species Human

IMPDH2 fusion protein - Ag3632 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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