| Gene Symbol |
IMPDH2
|
| Entrez Gene |
3615
|
| Alt Symbol |
IMPD2, IMPDH-II
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IMP (inosine 5'-monophosphate) dehydrogenase 2
|
| Other Description |
IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
|
| Swissprots |
P12268 Q6LEF3
|
| Accessions |
AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
|
| Function |
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
|
| Tissue Specificity |
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
|
| Top Pathways |
Purine metabolism, Drug metabolism - other enzymes
|
![Western Blot: IMPDH2 Overexpression Lysate (Adult Normal) [NBL1-11987] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IMPDH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5604_IMPDH2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11987-img0002.jpg)