IMPDH2

Gene Symbol	IMPDH2
Entrez Gene	3615
Alt Symbol	IMPD2, IMPDH-II
Species	Human
Gene Type	protein-coding
Description	IMP (inosine 5'-monophosphate) dehydrogenase 2
Other Description	IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
Swissprots	P12268 Q6LEF3
Accessions	AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity	IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-IMPDH2-cDNA-Clone - DC01876 from Abgent, a WuXi AppTec company Prices $693.90 Sizes 10 µg Species Human Accession BC006124

IMPDH2 - MBS1273729 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC006124

Human IMPDH2 cDNA clone(NM_000884.2) - CDFH009242 from Creative Biomart Species Human Accession NM_000884.2

Human IMPDH2 ORF Clone(NM_000884.2) - CDCL167221 from Creative Biomart Species Human Accession NM_000884.2

Human IMPDH2 ORF Clone(NM_000884.2) - CDCR337923 from Creative Biomart Species Human Accession NM_000884.2

Human IMPDH2 ORF Clone(NM_000884.2) - CDCR337924 from Creative Biomart Species Human Accession NM_000884.2

Human IMPDH2 Gene ORF cDNA clone in cloning vector - HG14878-G from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-His tag - HG14878-NH from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-His tag - HG14878-CH from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14878-ACR from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14878-ANR from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14878-CY from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid - HG14878-UT from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14878-NF from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14878-ACG from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14878-CF from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14878-NM from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14878-CM from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14878-NY from Sino Biological Species Human

Human IMPDH2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14878-ANG from Sino Biological Species Human

Mouse IMPDH2 ORF clone (NM_000884.2) - CDCL120855 from Creative biogene Species Human

Human IMPDH2 ORF Clone (BC006124) - CDCS405972 from Creative biogene Species Human Accession P12268

Human IMPDH2 ORF clone (BC006124) - CDCB158694 from Creative biogene Species Human

Human IMPDH2 cDNA Clone(NM_000884.2) - CDFH009242 from Creative biogene Species Human

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