| Gene Symbol | IMPDH2 |
|---|---|
| Entrez Gene | 3615 |
| Alt Symbol | IMPD2, IMPDH-II |
| Species | Human |
| Gene Type | protein-coding |
| Description | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| Other Description | IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2 |
| Swissprots | P12268 Q6LEF3 |
| Accessions | AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875 |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}. |
| Tissue Specificity | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
| Top Pathways | Purine metabolism, Drug metabolism - other enzymes |