NDN

Gene Symbol	NDN
Entrez Gene	4692
Alt Symbol	HsT16328, PWCR
Species	Human
Gene Type	protein-coding
Description	necdin, melanoma antigen (MAGE) family member
Other Description	Prader-Willi syndrome chromosome region|necdin|necdin homolog
Swissprots	B2R6Z5 Q99608
Accessions	BAA22660 EAW57610 Q99608 AK129654 AK312779 BAG35642 BC008750 AAH08750 HQ448156 ADQ32637 KJ534888 AHW56528 KJ535010 AHW56649 U35139 AAB39469 NM_002487 NP_002478
Function	Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.
Subcellular Location	Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Tissue Specificity	Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NDN 293T Cell Transient Overexpression Lysate(Denatured) - H00004692-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NDN 293 Cell Lysate - 400839 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Mouse

Necdin Overexpression Lysate (Denatured) - H00004692-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Necdin Overexpression Lysate (Native) - NBL1-13526 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NDN Over-expression Lysate Product - GWB-F208CA from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human NDN Knockdown Stable Cell Line - CSC-DC010214 from Creative biogene Category Cell Line Species Human

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