NDN

Gene Symbol NDN
Entrez Gene 4692
Alt Symbol HsT16328, PWCR
Species Human
Gene Type protein-coding
Description necdin, melanoma antigen (MAGE) family member
Other Description Prader-Willi syndrome chromosome region|necdin|necdin homolog
Swissprots B2R6Z5 Q99608
Accessions BAA22660 EAW57610 Q99608 AK129654 AK312779 BAG35642 BC008750 AAH08750 HQ448156 ADQ32637 KJ534888 AHW56528 KJ535010 AHW56649 U35139 AAB39469 NM_002487 NP_002478
Function Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.
Subcellular Location Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Tissue Specificity Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons.

NDN - MBS1271898 from MyBioSource

Species Human
Accession BC008750

Human NDN cDNA clone(NM_002487.2) - CDFH012289 from Creative Biomart

Species Human
Accession NM_002487.2

Human NDN ORF Clone(NM_002487.2) - CDCR283332 from Creative Biomart

Species Human
Accession NM_002487.2

Human NDN ORF Clone(NM_002487.2) - CDCR283333 from Creative Biomart

Species Human
Accession NM_002487.2

Human NDN ORF Clone(NM_002487.2) - CDCR283334 from Creative Biomart

Species Human
Accession NM_002487.2

Mouse NDN ORF clone (NM_002487.2) - CDCL137065 from Creative biogene

Species Human

Human NDN ORF Clone (BC008750) - CDCS410816 from Creative biogene

Species Human
Accession Q99608

Human NDN cDNA Clone(NM_002487.2) - CDFH012289 from Creative biogene

Species Human
Search more