NDN

Gene Symbol	NDN
Entrez Gene	4692
Alt Symbol	HsT16328, PWCR
Species	Human
Gene Type	protein-coding
Description	necdin, melanoma antigen (MAGE) family member
Other Description	Prader-Willi syndrome chromosome region|necdin|necdin homolog
Swissprots	B2R6Z5 Q99608
Accessions	BAA22660 EAW57610 Q99608 AK129654 AK312779 BAG35642 BC008750 AAH08750 HQ448156 ADQ32637 KJ534888 AHW56528 KJ535010 AHW56649 U35139 AAB39469 NM_002487 NP_002478
Function	Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.
Subcellular Location	Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Tissue Specificity	Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Necdin full length protein - ab114538 from Abcam Category Protein Source Wheat germ Species Human

NDN / Necdin Antibody Blocking Peptide - LS-E3677 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDN / Necdin Antibody Blocking Peptide - LS-E20448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Necdin Protein - H00004692-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NDN-Antibody-N-term-Blocking-Peptide - BP14876a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NDN Blocking Peptide - 33R-9426 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Necdin - H00004692-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Necdin - H00004692-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NDN fusion protein - ag7243 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NDN fusion protein - ag7077 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NDN - NDN-30373TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Necdin (NDN) - RPJ541Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Necdin (NDN) - RPJ541Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Necdin(NDN) - CSB-YP859515HU CSB-EP859515HU CSB-BP859515HU CSB-MP859515HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Necdin - TP300448 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NDN-Blocking-Peptide-N-term - BP20885b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NDN Peptide, Human - M34GP10214H from Creative Peptides Category Peptide Source Synthetic. Species Human

Necdin Recombinant Protein Antigen - NBP2-57334PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Necdin (NDN), Recombinant Protein - MBS1299993 from MyBioSource Category Protein Prices $1,080.00, $1,080.00, $1,310.00, $1,310.00, $1,695.00, $1,695.00, $2,160.00, $2,160.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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